The current paradigm in the amyloid hypothesis brands small β-amyloid (Aβ) oligomers as
the toxic species in Alzheimer's disease (AD). These oligomers are fibril-like; contain β-sheet …

Amyloidogenesis has been implicated in a broad spectrum of diseases in which amyloid
protein is invariably misfolded and deposited in cells and organs. Alzheimer's disease is one …

The two hallmarks of Alzheimer's disease (AD) are the presence of neurofibrillary tangles
(NFT) made of aggregates of the hyperphosphorylated tau protein and of amyloid plaques …

Although the amyloid (abeta peptide, Aβ) hypothesis is 25 years old, is the dominant model
of Alzheimer's disease (AD) pathogenesis, and guides the development of potential …

Amyloid beta (Aβ), the hallmark of Alzheimer's Disease (AD), now appears to be deleterious
in its low number aggregate form as opposed to the macroscopic Aβ fibers historically seen …

The association of the amyloid-β (Aβ) peptide with cellular membranes is hypothesized to be
the underlying phenomenon of neurotoxicity in Alzheimer's disease. Misfolding of proteins …

Several lines of evidence suggest that a characteristic of the neuropathology of Alzheimer's
disease (AD) is the aggregation of the amyloid beta peptides (Aβ), fragments of the human …

Amyloid-β (Aβ) peptide is one of the most promising targets for the development of new
therapies for Alzheimer's disease (AD). A growing body of evidence suggests a key …

Amyloid beta (Aβ) oligomers are the most neurotoxic aggregates causing neuronal death
and cognitive damage. A detailed elucidation of the aggregation pathways from oligomers to …

Aggregation and the formation of oligomeric intermediates of amyloid-β (Aβ) at the
membrane interface of neuronal cells are implicated in the cellular toxicity and pathology of …