Peptide-based vaccines: current progress and future challenges

RJ Malonis, JR Lai, O Vergnolle - Chemical reviews, 2019 - ACS Publications
Vaccines have had a profound impact on the management and prevention of infectious
disease. In addition, the development of vaccines against chronic diseases has attracted …

More than one reason to rethink the use of peptides in vaccine design

AW Purcell, J McCluskey, J Rossjohn - Nature reviews Drug discovery, 2007 - nature.com
The use of peptides as therapeutics is experiencing renewed enthusiasm owing to
advances in delivery, stability and design. Moreover, there is a growing emphasis on the use …

Epitope discovery and their use in peptide based vaccines

NL Dudek, P Perlmutter, I Aguilar… - Current …, 2010 - ingentaconnect.com
With recent advances in the design and delivery of peptide-based therapeutics there has
been a growing interest in the use of peptides in vaccine design. Moreover, functional …

Peptide-based vaccines

RJ Nevagi, I Toth, M Skwarczynski - Peptide applications in biomedicine …, 2018 - Elsevier
Vaccination is a cost-effective approach to prevent, treat, and eradicate infectious diseases
and cancer. Classical whole-organism vaccines may have several pitfalls such as the …

Peptide vaccine: progress and challenges

W Li, MD Joshi, S Singhania, KH Ramsey, AK Murthy - Vaccines, 2014 - mdpi.com
Conventional vaccine strategies have been highly efficacious for several decades in
reducing mortality and morbidity due to infectious diseases. The bane of conventional …

[HTML][HTML] Approaches to improve chemically defined synthetic peptide vaccines

BJ Hos, E Tondini, SI Van Kasteren… - Frontiers in …, 2018 - frontiersin.org
Progress made in peptide-based vaccinations to induce T-cell-dependent immune
responses against cancer has invigorated the search for optimal vaccine modalities. Design …

Peptides for vaccine development

IW Hamley - ACS Applied Bio Materials, 2022 - ACS Publications
This review discusses peptide epitopes used as antigens in the development of vaccines in
clinical trials as well as future vaccine candidates. It covers peptides used in potential …

[HTML][HTML] Peptide based therapeutics and their use for the treatment of neurodegenerative and other diseases

MH Baig, K Ahmad, M Saeed, AM Alharbi… - Biomedicine & …, 2018 - Elsevier
Bioactive peptides are actively involved in different biological functions and importantly
contribute to human health, and the use of peptides as therapeutics has a long successful …

Design and development of synthetic peptide vaccines: past, present and future

MS Bijker, CJM Melief, R Offringa… - Expert review of …, 2007 - Taylor & Francis
Synthetic peptide vaccines aiming at the induction of a protective CD8+ T-cell response
against infectious or malignant diseases are widely used in the clinic but, despite their …

Improved peptide vaccine strategies, creating synthetic artificial infections to maximize immune efficacy

SH van der Burg, MS Bijker, MJP Welters… - Advanced drug delivery …, 2006 - Elsevier
Soon after it was realized that T-cells recognize their target antigens as small protein
fragments or peptides presented by MHC molecules at the cell surface, these peptide …