The renal proximal tubule is a main target for drug-induced toxicity. The prediction of
proximal tubular toxicity during drug development remains difficult. Any in vitro methods …

The kidney is a major target for drug-induced toxicity, and the renal proximal tubule is
frequently affected. Nephrotoxicity is typically detected only late during drug development …

The kidney is one of the major target organs for drug-induced toxicity. The renal proximal
tubule is frequently affected due to its roles in drug transport and in concentrating the …

In vitro screens for nephrotoxicity are currently poorly predictive of toxicity in humans.
Although the functional proteins that are expressed by nephron tubules and mediate drug …

The kidney is a major target for xenobiotics, which include drugs, industrial chemicals,
environmental toxicants and other compounds. Accurate methods for screening large …

Human kidney tissue can now be generated via the directed differentiation of human
pluripotent stem cells. This advance is anticipated to facilitate the modeling of human kidney …

Drug attrition related to kidney toxicity remains a challenge in drug discovery and
development. In vitro models established over the past 2 decades to supplement in vivo …

Cell therapy using renal progenitors differentiated from human embryonic stem cells
(hESCs) or induced pluripotent stem cells (hiPSCs) has the potential to significantly reduce …

Kidney diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD),
which can progress to end stage renal disease (ESRD), are a worldwide health burden …

Drug-induced liver toxicity is a main reason for withdrawals of new drugs in late clinical
phases and post-launch of the drugs. Thus, hepatotoxicity screening of drug candidates in …