Nuclear hormone receptors comprise a large superfamily of ligand-modulated transcription
factors that, in part, mediate response to steroids, retinoids and thyroid hormones and play …

Following the successful cloning of the orphan nuclear receptors during the 1990s we
entered the 21st century with knowledge of the full complement of human nuclear receptors …

Nuclear receptors comprise a large family of proteins that shares a common structure and
mechanism of action. Members of this family, first cloned 20 years ago, are regulated by …

The nuclear receptor superfamily includes many receptors, identified based on their
similarity to steroid hormone receptors but without a known ligand. The study of how these …

Nuclear hormone receptors are ligand-activated transcription factors that regulate gene
expression and play a critical role in endocrine signaling. Orphan nuclear receptors belong …

II. Nuclear Receptors: General Concepts A. Anatomy of nuclear receptors B. Mechanisms of
action III. Orphan Nuclear Receptors A. Definition

Orphan nuclear receptors (NRs) 1 include gene products that are structurally related to
nuclear hormone receptors but lack known physiological ligands. It has become clear that …

Nuclear receptors play important roles in cellular regulation, providing direct links between
extracellular hormonal signals and transcriptional responses. Many of these molecules are …

The nuclear receptor superfamily is comprised of over 150 different proteins that have
evolved to mediate a complex array of extracellular signals into transcriptional responses …

The nuclear receptor superfamily, a group of structurally related, ligand-dependent
transcription factors, includes a large number of orphan receptors for which no ligand has …