Plasmodium falciparum (Pf) parasite development in liver represents the initial step of the
life-cycle in the human host after a Pf-infected mosquito bite. While an attractive stage for life …

Plasmodium falciparum parasites develop in the liver before being released into the
bloodstream, where they exert the potentially lethal effects characteristic of malaria. Our …

Plasmodium falciparum, which causes the most lethal form of human malaria, replicates in
the host liver during the initial stage of infection. However, in vivo malaria liver-stage (LS) …

Plasmodium falciparum (Pf) is a major cause of human malaria and is transmitted by
infected Anopheles mosquitoes. The initial asymptomatic infection is characterized by …

The exoerythrocytic stage of Plasmodium falciparum has remained a difficult phase of the
parasite life-cycle to study. The host and tissue specificity of the parasite requires the …

The Plasmodium liver stage is an attractive target for the development of antimalarial drugs
and vaccines, as it provides an opportunity to interrupt the life cycle of the parasite at a …

Invasion of hepatocytes by Plasmodium sporozoites deposited by Anopheles mosquitoes,
and their subsequent transformation into infective merozoites is an obligatory step in the …

Difficulties with inducing sterile and long lasting protective immunity against malaria with
subunit vaccines has renewed interest in vaccinations with attenuated Plasmodium …

In vitro studies of liver stage (LS) development of the human malaria parasite Plasmodium
falciparum are technically challenging; therefore, fundamental questions about hepatocyte …

Highlights•Malaria sporozoites are highly selective for their hepatocyte host.•Malaria
parasites refine the host during their liver stage of development.•Novel approaches and …