The tricarboxylic acid (TCA) cycle is capable of providing sufficient energy for the
physiological activities under aerobic conditions. Although tumor metabolic reprogramming …

The tricarboxylic acid (TCA) cycle is capable of providing sufficient energy for the
physiological activities under aerobic conditions. Although tumor metabolic reprogramming …

The tricarboxylic acid (TCA) cycle is a central route for oxidative phosphorylation in cells,
and fulfills their bioenergetic, biosynthetic, and redox balance requirements. Despite early …

The tricarboxylic acid cycle (TCA cycle) has been known for decades as a hub for
generating cellular energy and precursors for biosynthetic pathways. Several cancers …

Tumor cells carry various genetic and metabolic alterations, which directly contribute to their
growth and malignancy. Links between metabolism and cancer are multifaceted. Metabolic …

Metabolic networks support cancer cell survival, proliferation, and malignant progression.
Cancer cells take up large amounts of nutrients such as glucose and glutamine whose …

Citrate plays a central role in cancer cells' metabolism and regulation. Derived from
mitochondrial synthesis and/or carboxylation of α-ketoglutarate, it is cleaved by ATP-citrate …

Significance: The tricarboxylic acid (TCA) cycle is a housekeeping metabolic pathway
essential for generation of energy and biosynthetic intermediates. Alterations of the TCA …

Cancers cells strongly stimulate glycolysis and glutaminolysis for their biosynthesis.
Pyruvate derived from glucose is preferentially diverted towards the production of lactic acid …

With the foundation pre-laid, research in the new millennium has readily excavated and
expanded upon the architectural framework laid out by Otto Warburg's seminal work in a …