The cerebellum, a primary brain structure involved in the control of sensorimotor tasks, also
contributes to higher cognitive functions including reward, emotion and social interaction …

Escalated aggression can have devastating societal consequences, yet underlying
neurobiological mechanisms are poorly understood. Here, we show significantly increased …

The D3 dopamine receptor, a member of the Gi-coupled D2 family of dopamine receptors, is
expressed throughout limbic circuits affected in neuropsychiatric disorders, including …

Adolescence is a developmental period in which the mesolimbic dopaminergic “reward”
circuitry of the brain, including the nucleus accumbens (NAc), undergoes significant …

Abstract Dopamine D2 receptors (D2R) are G protein–coupled receptors that modulate
synaptic transmission and are important for various brain functions, including learning and …

Background Studies in humans and nonhuman primates have identified a region of the
dentate nucleus of the cerebellum, or the lateral cerebellar nucleus (LCN) in rodents …

Dopamine signaling through D1 receptors in the prefrontal cortex (PFC) plays a critical role
in the maintenance of higher cognitive functions, such as working memory. At the cellular …

Evidence of direct reciprocal connections between the cerebellum and basal ganglia has
challenged the long-held notion that these structures function independently. While …

Dopamine modulation in the prefrontal cortex is important for cognitive processing and
disrupted in diverse neuropsychiatric diseases. Activation of D1 receptors is thought to …

Dopamine modulation in the prefrontal cortex (PFC) mediates diverse effects on neuronal
physiology and function, but the expression of dopamine receptors at subpopulations of …