Figura 1.-Trials con statine nei vari profili di rischio cardiovascolare mg/die, e soprattutto nel
PROVE-IT [13] che confrontava atorvastatina 80 mg/die vs pravastatina 40 mg/die. Una meta …

Negli ultimi anni grandi trial randomizzati hanno dimostrato che la riduzione del colesterolo
LDL mediante la terapia con statine riduce la mortalità e la morbilità vascolare nei soggetti …

Ullevål University Hospital, Oslo, Norway patients with and without pretreatment with statins.
They also tried to elucidate whether such pretreatment would have impact on the outcome of …

Cholesterol lowering with statin therapy has been shown to reduce cardiovascular events in
a variety of patient categories, ranging from patients with established cardiovascular disease …

Although lipid-lowering therapy in patients with established coronary heart disease
(secondary prevention) is generally accepted, its benefit is often questioned in asympto …

Cardiovascular disease has an elevated prevalence in the general population, with
increasing incidence with advancing age. Epidemiological studies clearly show that higher …

The results of recent landmark clinical trials indicate that statin treatment reduces coronary
artery disease morbidity and mortality in subjects with a history of angina pectoris or …

SummaryAlthough treatment with HMG-CoA reductase inhibitors (statins) to reduce total and
LDL-cholesterol is clearly indicated in patients with coronary heart disease (CHD) and those …

In the context of the growing complexity of atherosclerosis, LDL-cholesterol has been
gradually revealed to be the main aetiological agent. However, the first clinical trials were …

Charles Howard Chandler Professor of Internal Medicine, Director, Division of
Arteriosclerosis and Lipid Metabolism, Emory University School of Medicine, Atlanta …