[HTML][HTML] Bone marrow mononuclear cells for joint therapy: the role of macrophages in inflammation resolution and tissue repair

BC Menarim, JN MacLeod… - World Journal of Stem …, 2021 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is the most prevalent joint disease causing major disability and medical
expenditures. Synovitis is a central feature of OA and is primarily driven by macrophages …

[HTML][HTML] Mesenchymal stem cell-based therapy of osteoarthritis: Current knowledge and future perspectives

CR Harrell, BS Markovic, C Fellabaum… - Biomedicine & …, 2019 - Elsevier
Osteoarthritis (OA) is a chronic, prevalent, debilitating joint disease characterized by
progressive cartilage degradation, subchondral bone remodeling, bone marrow lesions …

[HTML][HTML] Mesenchymal stem cells: Current concepts in the management of inflammation in osteoarthritis

AA Nurul, M Azlan, MR Ahmad Mohd Zain… - Biomedicines, 2021 - mdpi.com
Osteoarthritis (OA) has traditionally been known as a “wear and tear” disease, which is
mainly characterized by the degradation of articular cartilage and changes in the …

[HTML][HTML] Revolutionizing osteoarthritis treatment: How mesenchymal stem cells hold the key

R Tian, S Su, Y Yu, S Liang, C Ma, Y Jiao… - Biomedicine & …, 2024 - Elsevier
Osteoarthritis (OA) is a multifaceted disease characterized by imbalances in extracellular
matrix metabolism, chondrocyte and synoviocyte senescence, as well as inflammatory …

[HTML][HTML] Cell-based therapies have disease-modifying effects on osteoarthritis in animal models. A systematic review by the ESSKA Orthobiologic Initiative. Part 2 …

A Boffa, C Perucca Orfei, Y Sourugeon, L Laver… - Knee Surgery, Sports …, 2023 - Springer
Purpose Aim of this systematic review was to determine if bone marrow-derived cell-based
injectable therapies induce disease-modifying effects in joints affected by osteoarthritis (OA) …

[HTML][HTML] Pro-regenerative dialogue between macrophages and mesenchymal stem/stromal cells in osteoarthritis

C Bohaud, R Contreras-Lopez, J De La Cruz… - Frontiers in Cell and …, 2021 - frontiersin.org
Osteoarthritis (OA), the most common degenerative and inflammatory joint disorder, is
multifaceted. Indeed, OA characteristics include cartilage degradation, osteophytes …

The challenge and the promise of bone marrow cells for human cartilage repair

CR Chu - Cartilage, 2015 - journals.sagepub.com
The cartilage repair potential of bone marrow–derived stem cells has been well described.
Harnessing this potential for human articular cartilage repair remains challenging …

[HTML][HTML] Mesenchymal stem cells in osteoarthritis therapy: a review

C Zhu, W Wu, X Qu - American journal of translational research, 2021 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is a chronic joint disease that generally occurs worldwide with pain and
disability. The progression is slow, and it is mostly diagnosed midlife and often disturbs the …

[HTML][HTML] Advances in mesenchymal stem cell therapy for osteoarthritis: from preclinical and clinical perspectives

Z Lv, X Cai, Y Bian, Z Wei, W Zhu, X Zhao, X Weng - Bioengineering, 2023 - mdpi.com
The prevalence of osteoarthritis (OA), a degenerative disorder of joints, has substantially
increased in recent years. Its key pathogenic hallmarks include articular cartilage …

Mesenchymal stem cell therapy for osteoarthritis: current perspectives

CC Wyles, MT Houdek, A Behfar… - Stem cells and cloning …, 2015 - Taylor & Francis
Osteoarthritis (OA) is a painful chronic condition with a significant impact on quality of life.
The societal burden imposed by OA is increasing in parallel with the aging population; …