Interferometric scattering microscopy (iSCAT) is an extremely sensitive imaging method
based on the efficient detection of light scattered by nanoscopic objects. The ability to, at …

Interferometric scattering microscopy (iSCAT) is a light scattering-based imaging modality
that offers a unique combination of imaging speed and precision for tracking nanoscopic …

Optical microscopes have for centuries been our window to the microscopic world. The
advent of single-molecule optics over the past few decades has ushered in a new era in …

Fluorescence microscopy has been the workhorse for investigating optical phenomena at
the nanometer scale but this approach confronts several fundamental limits. As a result …

Despite recent remarkable advances in microscopic techniques, it still remains very
challenging to directly observe the complex structure of cytoplasmic organelles in live cells …

Microscopy based on the interferometric detection of light scattered from nanoparticles
(iSCAT) was introduced in our laboratory more than a decade ago. In this work, we present …

Our ability to optically interrogate nanoscopic objects is controlled by the difference between
their extinction cross sections and the diffraction-limited area to which light can be confined …

Many of the biological functions of a cell are dictated by the intricate motion of proteins within
its membrane over a spatial range of nanometres to tens of micrometres and time intervals of …

Bright-field light microscopy and related phase-sensitive techniques play an important role
in life sciences because they provide facile and label-free insights into biological specimens …

Current in vitro optical studies of microtubule dynamics tend to rely on fluorescent labeling of
tubulin, with tracking accuracy thereby limited by the quantum yield of fluorophores and by …