Ferroptosis is a nonapoptotic form of cell death characterized by iron-dependent lipid
peroxidation and has been implicated in multiple pathological conditions. Glutathione …

Ferroptosis is an iron-dependent form of oxidative cell death induced by lipid peroxidation
accumulation. Glutathione peroxidase 4 (GPX4) plays a key role in the regulation of …

Ferroptosis, a new form of non-apoptotic, regulated cell death characterized by iron
dependency and lipid peroxidation, is involved in many pathological conditions such as …

Ferroptosis is a novel form of oxidative cell death triggered by iron-dependent lipid
peroxidation. The induction of ferroptosis presents an attractive therapeutic strategy for …

Ferroptosis is inhibited by glutathione peroxidase 4 (GPX4), an antioxidant enzyme that
uses reduced glutathione (GSH) as a cofactor to detoxify lipid hydroperoxides. As a …

Ferroptosis, a regulated cell death hallmarked by unrestrained lipid peroxidation, plays a
pivotal role in the pathophysiology of various diseases, making it a promising therapeutic …

Ferroptosis induced by GPX4 inhibition offers promise for killing drug-resistant cancer cells,
yet current GPX4 inhibitors lack selectivity. The discovery of masked nitrile oxide …

I read with great interest the work by Lee et al., in which apoptotic agent TRAIL in
combination with erastin significantly induces apoptosis with oligomerization of Bax and …

Ferroptosis is a new form of regulated, non‐apoptotic cell death driven by iron‐dependent
phospholipid peroxidation. Its therapeutic potential is however, greatly limited by the low …

Ferroptosis is defined as cell death triggered by iron-dependent lipid peroxidation that is
preventable by antioxidant compounds such as ferrostatin-1. Endogenous suppressors of …