[HTML][HTML] Gene expression profiles in mesenchymal stromal cells from bone marrow, adipose tissue and lung tissue of COPD patients and controls

D Kruk, ACY Yeung, A Faiz, NHT Ten Hacken… - Respiratory …, 2023 - Springer
Background Chronic obstructive pulmonary disease (COPD) is characterized by irreversible
lung tissue damage. Novel regenerative strategies are urgently awaited. Cultured …

Functional characterisation of bone marrow-derived mesenchymal stromal cells from COPD patients

W Broekman, H Roelofs, MC Zarcone… - ERJ Open …, 2016 - Eur Respiratory Soc
Autologous bone marrow-derived mesenchymal stromal cells (BM-MSCs) are evaluated for
clinical use in chronic obstructive pulmonary disease (COPD) patients, but it is unclear …

Transcriptional profiling of circulating mononuclear cells from patients with chronic obstructive pulmonary disease receiving mesenchymal stromal cell infusions

JD Armitage, DBA Tan, M Sturm… - Stem Cells …, 2021 - academic.oup.com
Chronic obstructive pulmonary disease (COPD) is an inflammatory airways disease with
limited therapeutic options. We have previously shown that mesenchymal stromal cell (MSC) …

Abnormalities in reparative function of lung-derived mesenchymal stromal cells in emphysema

DMLW Kruk, M Wisman, HG Bruin… - … of Physiology-Lung …, 2021 - journals.physiology.org
Mesenchymal stromal cells (MSCs) may provide crucial support in the regeneration of
destructed alveolar tissue (emphysema) in chronic obstructive pulmonary disease (COPD) …

[HTML][HTML] Preclinical studies of mesenchymal stem cell (MSC) administration in chronic obstructive pulmonary disease (COPD): a systematic review and meta-analysis

X Liu, Q Fang, H Kim - PloS one, 2016 - journals.plos.org
Background In the last two decades, mesenchymal stem cells (MSCs) have been pre-
clinically utilized in the treatment of a variety of kinds of diseases including chronic …

Mesenchymal stromal cells are readily recoverable from lung tissue, but not the alveolar space, in healthy humans

KA Sinclair, ST Yerkovich, T Chen, JL McQualter… - Stem Cells, 2016 - academic.oup.com
Stromal support is critical for lung homeostasis and the maintenance of an effective
epithelial barrier. Despite this, previous studies have found a positive association between …

[HTML][HTML] Single-cell sequencing of lung macrophages and monocytes reveals novel therapeutic targets in COPD

Y Hu, X Shao, L Xing, X Li, GM Nonis, GJ Koelwyn… - Cells, 2023 - mdpi.com
Background: Macrophages and monocytes orchestrate inflammatory processes in the lungs.
However, their role in the pathogenesis of chronic obstructive pulmonary disease (COPD) …

Mesenchymal stem cell trials for pulmonary diseases

MA Antunes, JG Laffey, P Pelosi… - Journal of cellular …, 2014 - Wiley Online Library
All adult tissues, including the lung, have some capacity to self‐repair or regenerate through
the replication and differentiation of stem cells resident within these organs. While lung …

[PDF][PDF] Characterization of mesenchymal stem cells obtained from human lungs with and without idiopathic pulmonary fibrosis

A Jahn, C Rio, A Montes, A Martin-Medina, PJ Pont… - Eur Respir …, 2019 - researchgate.net
Mesenchymal stem cells have been reported to be key mediators of the regeneration and
repair processes in chronic lung diseases (Gallicchio et al. 2019; Cancio et al. 2018) …

Stem cell treatment reduces T cell apoptosis in COPD patients with chronic bronchitis but not with emphysema

E Eryüksel, Z Tunca, Z Mercancı, SS Kılıç, D Kocakaya… - Tissue and Cell, 2024 - Elsevier
Background Chronic obstructive pulmonary disease (COPD) is a prevalent and preventable
condition. Mesenchymal stem cell (MSC) therapy is being explored to aid in the …