The hypothesis for this dissertation is that cyclooxygenase-2 (Cox-2) and its product
prostaglandin E2 (PGE2) directly regulate proliferation, invasion, angiogenesis, aromatase …

To evaluate the direct effect of human cyclooxygenase-2 (hCox-2) on human breast tumor
cell proliferation, invasion, and angiogenesis, hCox-2 cDNA was transfected into slow …

Overexpression of human cyclooxygenase 2 (COX-2) in the mammary glands of transgenic
mice induces tissue-specific tumorigenic transformation. However, the molecular …

PURPOSE: This study investigates the COX-2 expression in human primary breast
carcinomas and its relationship with both angiogenesis and the expression of estrogen …

It is generally accepted that cyclooxygenase (COX)-2 is involved in tumorigenesis. However,
the molecular mechanisms by which COX-2 regulates tumorigenesis have not been clearly …

To investigate the effects of cyclooxygenase‐2 (COX‐2) overexpression on breast cancer
development, we stably transfected MCF‐10F human breast epithelial cells with an …

Abstract Cyclooxygenase-2 (COX-2), an inducible enzyme involved in prostaglandin
(including PGE2) biosynthesis, is overexpressed in several epithelial malignancies …

We had earlier shown that elevated cyclo-oxygenase (COX)-2 expression by breast cancer
cells promotes tumor progression and metastasis by multiple mechanisms: inactivation of …

Cyclooxygenase-2 (COX-2) overexpression is a widely recognized feature of human breast
cancer and inhibitors of the enzyme have antitumor effects in a subset of tumor settings …

Cancers form more prostaglandins than the normal tissues from which they arise.
Cyclooxygenase-2 (prostaglandin H synthase-2, PGHS-2, EC 1.14. 99.1), an enzyme that …