Drug-resistant mutant forms of an organism are likely to be less fit than their wild-type strains
in the absence of selection. Experimental work on prokaryotic organisms suggests that this …

Forces determining the rate of spread of drug resistance in malaria were explored using a
genetics transmission model which took account of the strong population structure of these …

Controlling the spread of antimalarial drug resistance, especially resistance of P lasmodium
falciparum to artemisinin‐based combination therapies, is a high priority. Available data …

A general method of investigating parasite population genetics is presented and used to
investigate the evolution of drug resistance in Plasmodium. The most important biological …

It is widely assumed in genetics that most mutations disrupt metabolism to some extent, and
are consequently likely to be disadvantageous for the organisms that inherit them. This may …

Malaria infections frequently consist of mixtures of drug-resistant and drug-sensitive
parasites. If crowding occurs, where clonal population densities are suppressed by the …

The pathogenesis of severe Plasmodium falciparum malaria is still obscure, but is believed
to be multi-factorial, and among the important factors are intrinsic parasite-properties. Here …

A succession of antimalarial drugs has been deployed to treat human falciparum malaria but
each has, in turn, been nullified by the spread of drug resistance. The consensus view has …

Recent population genetic studies on the malaria parasite Plasmodium falciparum have
confirmed that selfing is more frequent where the transmission rate is lower, with inbreeding …

Malaria, a leading parasitic disease, inflicts an enormous toll on human lives and is caused
by protozoal parasites belonging to the genus Plasmodium. Antimalarial drugs targeting …