The beneficial effects of physical activity on brain ageing are well recognised, with
exerkines, factors that are secreted into the circulation in response to exercise, emerging as …

Identifying therapeutics to delay, and potentially reverse, age-related cognitive decline is
critical in light of the increased incidence of dementia-related disorders forecasted in the …

Reversing brain aging may be possible through systemic interventions such as exercise. We
found that administration of circulating blood factors in plasma from exercised aged mice …

Exercise has been shown to positively augment adult hippocampal neurogenesis; however,
the cellular and molecular pathways mediating this effect remain largely unknown. Previous …

Platelet factors regulate wound healing and can signal from the blood to the brain,.
However, whether platelet factors modulate cognition, a highly valued and central …

In the modern medical era, more diverse and effective treatment options have translated to
increased life expectancy. With this increased life span comes increased age-associated …

Physical exercise is generally beneficial to all aspects of human and animal health, slowing
cognitive ageing and neurodegeneration. The cognitive benefits of physical exercise are …

Microglial activation and neuroinflammatory changes are characteristic of the aged brain
and contribute to age-related cognitive impairment. Exercise improves cognitive function in …

In the central nervous system, ageing results in a precipitous decline in adult neural
stem/progenitor cells and neurogenesis, with concomitant impairments in cognitive …

Physical activity is a strong positive physiological modulator of adult neurogenesis in the
hippocampal dentate gyrus. Although the underlying regulatory mechanisms are still …