Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …

Eye pain is an unpleasant sensory and emotional experience including sensory-
discriminative, emotional, cognitive, and behavioral components and supported by distinct …

This report characterizes the neurobiology of the ocular surface and highlights relevant
mechanisms that may underpin contact lens–related discomfort. While there is limited …

Physical and chemical agents acting on the ocular surface (extreme environmental
temperatures, wind, foreign bodies, and chemicals) elicit conscious sensations and reflex …

Ocular irritation and pain are associated with many clinical situations (eg accidental injury,
eye diseases, surgery and contact lens wearing). Pain and related ocular sensations begin …

Ocular surface pain is a frequent cause of visits to an eye care provider and has a
substantial impact on healthcare cost, yet a complete understanding of its causative factors …

The cornea is the most densely innervated and sensitive tissue in the body. The cornea is
exclusively innervated by C-and A-delta fibers, including mechano-nociceptors that are …

Dry eye disease (DED) affects. 10% of the population worldwide, and it provokes an
unpleasant sensation of ocular dryness, whose underlying neural mechanisms remain …

As the biological alarm of impending or actual tissue damage, pain is essential for our
survival. However, when it is initiated and/or sustained by dysfunctional elements in the …

Abstract The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms
involved in the initiation and perpetuation of dry eye disease. Its central mechanism is …