CHBP induces stronger immunosuppressive CD127+ M-MDSC via erythropoietin receptor

J Li, G Tu, W Zhang, Y Zhang, X Zhang, Y Qiu… - Cell Death & …, 2021 - nature.com
Erythropoietin (EPO) is not only an erythropoiesis hormone but also an immune-regulatory
cytokine. The receptors of EPO (EPOR) 2 and tissue-protective receptor (TPR), mediate …

IFN-γ decreased the suppressive function of CD33+ HLA-DRlow myeloid cells through down-regulation of PD-1/PD-L2 signaling pathway

X Zhan, S Hu, Y Wu, M Li, T Liu, S Ming, M Wu… - Molecular …, 2018 - Elsevier
Myeloid-derived suppressor cells (MDSCs) have recently been described to inhibit
protective T-cell responses in tuberculosis (TB). T cells play an important role in the …

Impact of erythropoietin production by erythroblastic island macrophages on homeostatic murine erythropoiesis

G Perron-Deshaies, P St-Louis, H Romero… - International Journal of …, 2020 - mdpi.com
Erythropoietin (EPO) is an essential hormone for erythropoiesis, protecting differentiating
erythroblasts against apoptosis. EPO has been largely studied in stress or pathological …

Non-erythropoietic tissue-protective peptides derived from erythropoietin: WO2009094172

F Dumont, P Bischoff - Expert opinion on therapeutic patents, 2010 - Taylor & Francis
Erythropoietin (EPO) is a cytokine with erythropoietic and tissue protective activities. Its
action as a tissue protective agent requires, however, high dosage that results in limiting …

From erythropoietin to its peptide derivatives: smaller but stronger

C Zhang, C Yang, T Zhu - Current Protein and Peptide Science, 2017 - ingentaconnect.com
Erythropoietin (EPO), recognized early as a tissue protective agent, can trigger
antiinflammatory and anti-apoptotic processes to delimit injury and promote repair by …

Modulation of cellular stress response via the erythropoietin/CD131 heteroreceptor complex in mouse mesenchymal-derived cells

S Bohr, SJ Patel, R Vasko, K Shen… - Journal of Molecular …, 2015 - Springer
Tissue-protective properties of erythropoietin (EPO) have let to the discovery of an
alternative EPO signaling via an EPO-R/CD131 receptor complex which can now be …

[HTML][HTML] Erythropoietin effects on dendritic cells: potential mediators in its function as an immunomodulator?

SP Sagiv, L Lifshitz, R Orkin, M Mittelman… - Experimental …, 2008 - Elsevier
OBJECTIVE: Modulatory effects of erythropoietin (EPO) on the cellular and humoral
compartments of the immune system have been described; however, the mechanism of …

[HTML][HTML] Linking erythropoietin to Treg-dependent allograft survival through myeloid cells

JK Horwitz, S Bin, RL Fairchild, KS Keslar, Z Yi… - JCI insight, 2022 - ncbi.nlm.nih.gov
Erythropoietin (EPO) has multiple nonerythropoietic functions, including immune
modulation, but EPO's effects in transplantation remain incompletely understood. We tested …

Erythropoietin: a potent inducer of peripheral immuno/inflammatory modulation in autoimmune EAE

RR Yuan, Y Maeda, W Li, W Lu, S Cook, P Dowling - PloS one, 2008 - journals.plos.org
Background Beneficial effects of short-term erythropoietin (EPO) therapy have been
demonstrated in several animal models of acute neurologic injury, including experimental …

Bon EPOtit! S1P-mediated EPO signaling whets a macrophage's appetite for apoptotic cells

JP Kolb, J Martinez - Immunity, 2016 - cell.com
Phagocytes clear dying cells within an organism to prevent damaging inflammation and
autoimmunity. In this issue of Immunity, Luo et al.(2016) describe how" find-me" signals from …