Co-administration of Luteolin mitigated toxicity in rats' lungs associated with doxorubicin treatment

SE Owumi, SO Nwozo, UO Arunsi, AK Oyelere… - Toxicology and applied …, 2021 - Elsevier
Doxorubicin (DOX), is a drug against lung malignancies with undesirable side effect
including oxidative, inflammatory and apoptotic effects. Luteolin (LUT), present in fruits and …

Luteolin attenuates doxorubicin-induced derangements of liver and kidney by reducing oxidative and inflammatory stress to suppress apoptosis

SE Owumi, DO Lewu, UO Arunsi… - Human & experimental …, 2021 - journals.sagepub.com
Doxorubicin is an effective anti-neoplastic agent; the reported toxicities of DOX limit its use.
Luteolin is a polyphenolic phytochemical that exhibits beneficial biological effects via …

Biochemical and histological alterations of doxorubicin‐induced neurotoxicity in rats: protective role of luteolin

IO Imosemi, SE Owumi… - Journal of Biochemical and …, 2022 - Wiley Online Library
Doxorubicin (DOX) is a chemotherapeutic drug used in the treatment of various cancer
types. DOX toxic side effects include neuronopathy and memory deficits. We investigated the …

Anti-tumor promoting potential of luteolin against 7, 12-dimethylbenz (a) anthracene-induced mammary tumors in rats

RP Samy, P Gopalakrishnakone… - Chemico-biological …, 2006 - Elsevier
In this study, we evaluated the anti-tumor potential of luteolin (30mg/kg, po), combined with
cyclophosphamide (10mg/kg, ip)(LU+ CYC) orally administered for 20 days; and CYC …

Protective effects of dietary luteolin against mercuric chloride-induced lung injury in mice: involvement of AKT/Nrf2 and NF-κB pathways

B Liu, H Yu, R Baiyun, J Lu, S Li, Q Bing… - Food and Chemical …, 2018 - Elsevier
Food-derived compound luteolin possesses multiple pharmacological activities.
Accordingly, we focused on exploring the protective effects of luteolin (100 mg/kg) against …

[HTML][HTML] Luteolin attenuates doxorubicin-induced cytotoxicity to MCF-7 human breast cancer cells

Y Sato, N Sasaki, M Saito, N Endo… - Biological and …, 2015 - jstage.jst.go.jp
Luteolin, a flavone found in some vegetables, has been reported to exhibit antioxidant,
antiinflammatory, and anticancer activities. In the present study, we found that luteolin has …

[HTML][HTML] Modulatory effect of luteolin on redox homeostasis and inflammatory cytokines in a mouse model of liver cancer

Q Zhang, J Yang, J Wang - Oncology Letters, 2016 - spandidos-publications.com
Liver cancer is one of the leading causes of cancer‑associated mortality worldwide. Due to
changes in lifestyle and daily exposure to various chemicals, which may lead to chemical …

[HTML][HTML] Luteolin, a flavonoid, as an anticancer agent: A review

M Imran, A Rauf, T Abu-Izneid, M Nadeem… - Biomedicine & …, 2019 - Elsevier
Many food-derived phytochemicals and their derivatives represent a cornucopia of new anti-
cancer compounds. Luteolin (3, 4, 5, 7-tetrahydroxy flavone) is a flavonoid found in different …

Lutein inhibits cell growth and activates apoptosis via the PI3K/AKT/mTOR signaling pathway in A549 human non-small-cell lung cancer cells

W Zhang, Y Zhao, Z Shi, D Cong… - Journal of …, 2018 - dl.begellhouse.com
Cancer, the uncontrolled growth of cells, is a major disease that threatens the worldwide
population. Among all cancer types, lung cancer has the highest morbidity rate, with a …

Protective effect of luteolin on cigarette smoke extract‑induced cellular toxicity and apoptosis in normal human bronchial epithelial cells via the Nrf2 pathway

X Tan, P Jin, L Feng, J Song, E Sun… - Oncology …, 2014 - spandidos-publications.com
Luteolin, one of the most common abundant flavonoids in vegetables and herbs, has
antitumor effects on various tumors by inducing apoptosis, antioxidant effects and inhibition …