Animal models have been used for a number of decades to study arthritis and have
contributed greatly to unravelling mechanisms of pathogenesis and validating new targets …

Animal models for rheumatic diseases complement human investigations to study in detail
pathogenic hypotheses and therapeutic strategies. An overview of animal studies in the last …

The development of novel treatments for rheumatoid arthritis (RA) requires the interplay
between clinical observations and studies in animal models. Given the complex molecular …

Advances in targeted immune therapeutics have profoundly improved clinical outcomes for
patients with inflammatory arthropathies particularly rheumatoid arthritis. The landscape of …

Arthritis literally means joint inflammation. Arthritis is not a single disease. Arthritis refers to a
group of rheumatic diseases and other conditions that can cause pain, stiffness and swelling …

Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by synovitis and
joint damage. The etiology of RA is multi-factorial including various genetic and …

The complex pathobiologic changes of human joint disease, particularly osteoarthritis (OA),
normally take several decades to develop and may be influenced by a multitude of genetic …

Animal models of arthritis are used to better understand pathophysiology of a disease or to
seek potential therapeutic targets or strategies. Focusing on models currently used for …

Abstract Models of rheumatoid arthritis (RA) in laboratory animals are important tools for
research into pathogenic mechanisms and the development of effective, safe therapies …

Rheumatoid arthritis (RA) is a chronic, inflammatory, and systemic autoimmune disease that
affects the connective tissue and primarily the joints. If not treated, RA ultimately leads to …