Leptin: a diverse regulator of neuronal function

J Harvey - Journal of neurochemistry, 2007 - Wiley Online Library
It is well documented that leptin is a circulating hormone that plays a key role in regulating
food intake and body weight via its actions on specific hypothalamic nuclei. However, leptin …

Leptin inhibits epileptiform‐like activity in rat hippocampal neurones via PI 3‐kinase‐driven activation of BK channels

LJ Shanley, D O'malley, AJ Irving… - The Journal of …, 2002 - Wiley Online Library
The obese gene product, leptin is an important circulating satiety factor that regulates energy
balance via its actions in the hypothalamus. However, leptin receptors are also expressed in …

[HTML][HTML] Leptin regulation of neuronal excitability and cognitive function

J Harvey - Current opinion in pharmacology, 2007 - Elsevier
Leptin, a hormone produced by adipocytes, provides signals to specific regions of the
hypothalamus to control energy homeostasis. However, the past decade of research has not …

Food for thought: Leptin and hippocampal synaptic function

J Harvey - Frontiers in Pharmacology, 2022 - frontiersin.org
It is well documented that the endocrine hormone, leptin controls energy homeostasis by
providing key signals to specific hypothalamic nuclei. However, our knowledge of leptin's …

Leptin: a multifaceted hormone in the central nervous system

J Harvey - Molecular neurobiology, 2003 - Springer
It is well established that the adipocyte-derived hormone leptin is an important circulating
satiety factor that regulates body weight and food intake via its actions on specific …

Novel actions of leptin in the hippocampus

J Harvey - Annals of medicine, 2003 - Taylor & Francis
It is well established that the obese gene product, leptin is an important circulating satiety
factor that signals nutritional status to specific hypothalamic nuclei involved in body weight …

Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels

LJ Shanley, AJ Irving, MG Rae, MLJ Ashford… - nature …, 2002 - nature.com
Leptin is an important circulating factor that regulates energy balance via the leptin receptor
Ob-Rb in the hypothalamus. Ob-Rb activation may inhibit hypothalamic neurons by …

Leptin regulation of neuronal morphology and hippocampal synaptic function

J Harvey - Frontiers in synaptic neuroscience, 2013 - frontiersin.org
The central actions of the hormone leptin in regulating energy homeostasis via the
hypothalamus are well documented. However, evidence is growing that this hormone can …

Regulation of hippocampal synaptic function by the metabolic hormone leptin: Implications for health and disease

A Irving, J Harvey - Progress in Lipid Research, 2021 - Elsevier
Significant advances have been made in our understanding of the hormone, leptin and its
CNS actions in recent years. It is now evident that leptin has a multitude of brain functions …

Leptin: a potential cognitive enhancer?

J Harvey, LJ Shanley, D O'Malley… - Biochemical Society …, 2005 - portlandpress.com
It is well documented that the hormone leptin signals information regarding the status of fat
stores to hypothalamic nuclei, which in turn control feeding behaviour and body weight …