Carbon monoxide–physiology, detection and controlled release
SH Heinemann, T Hoshi, M Westerhausen… - Chemical …, 2014 - pubs.rsc.org
Carbon monoxide (CO) is increasingly recognized as a cell-signalling molecule akin to nitric
oxide (NO). CO has attracted particular attention as a potential therapeutic agent because of …
oxide (NO). CO has attracted particular attention as a potential therapeutic agent because of …
Bioactivity and pharmacological actions of carbon monoxide-releasing molecules
R Motterlini, BE Mann, TR Johnson… - Current …, 2003 - ingentaconnect.com
Carbon monoxide (CO) is a resourceful gas as recent advances in the area of cell signaling
are revealing an unexpected physiological role for CO in the cardiovascular, immune and …
are revealing an unexpected physiological role for CO in the cardiovascular, immune and …
CORM‐A1: a new pharmacologically active carbon monoxide‐releasing molecule
R Motterlini, P Sawle, S Bains, J Hammad… - The FASEB …, 2005 - Wiley Online Library
Carbon monoxide (CO) is emerging as an important and versatile mediator of physiological
processes to the extent that treatment of animals with exogenous CO gas has beneficial …
processes to the extent that treatment of animals with exogenous CO gas has beneficial …
Carbon monoxide and its controlled release: therapeutic application, detection, and development of carbon monoxide releasing molecules (CORMs) miniperspective
K Ling, F Men, WC Wang, YQ Zhou… - Journal of Medicinal …, 2017 - ACS Publications
Carbon monoxide (CO) is attracting increasing attention because of its role as a
gasotransmitter with cytoprotective and homeostatic properties. Carbon monoxide releasing …
gasotransmitter with cytoprotective and homeostatic properties. Carbon monoxide releasing …
Developing drug molecules for therapy with carbon monoxide
The use of Carbon Monoxide (CO) as a therapeutic agent has already been tested in human
clinical trials. Pre-clinically, CO gas administration proved beneficial in animal models of …
clinical trials. Pre-clinically, CO gas administration proved beneficial in animal models of …
Development of triggerable, trackable, and targetable carbon monoxide releasing molecules
LS Lazarus, AD Benninghoff… - Accounts of chemical …, 2020 - ACS Publications
Conspectus Carbon monoxide (CO) is a gaseous signaling molecule produced in humans
via the breakdown of heme in an O2-dependent reaction catalyzed by heme oxygenase …
via the breakdown of heme in an O2-dependent reaction catalyzed by heme oxygenase …
Controlled therapeutic delivery of CO from carbon monoxide-releasing molecules (CORMs)
Carbon monoxide (CO) has been regarded as a “silent killer” for its toxicity toward biological
systems. However, a low concentration of endogenously produced CO has shown a number …
systems. However, a low concentration of endogenously produced CO has shown a number …
Strategies toward organic carbon monoxide prodrugs
Conspectus Carbon monoxide is widely acknowledged as an important gasotransmitter in
the mammalian system with importance on par with that of nitric oxide. It has also been firmly …
the mammalian system with importance on par with that of nitric oxide. It has also been firmly …
A click-and-release approach to CO prodrugs
Carbon monoxide belongs to the family of signaling molecules and has been shown to
possess therapeutic effects. Similar to NO, safe delivery of CO is a key issue in developing …
possess therapeutic effects. Similar to NO, safe delivery of CO is a key issue in developing …
Therapeutic applications of carbon monoxide-releasing molecules
R Motterlini, BE Mann, R Foresti - Expert opinion on investigational …, 2005 - Taylor & Francis
Carbon monoxide (CO), which is formed in mammalian cells through the oxidation of haem
by the enzyme haem oxygenase, actively participates in the regulation of key intracellular …
by the enzyme haem oxygenase, actively participates in the regulation of key intracellular …