Carbon monoxide–physiology, detection and controlled release

SH Heinemann, T Hoshi, M Westerhausen… - Chemical …, 2014 - pubs.rsc.org
Carbon monoxide (CO) is increasingly recognized as a cell-signalling molecule akin to nitric
oxide (NO). CO has attracted particular attention as a potential therapeutic agent because of …

Bioactivity and pharmacological actions of carbon monoxide-releasing molecules

R Motterlini, BE Mann, TR Johnson… - Current …, 2003 - ingentaconnect.com
Carbon monoxide (CO) is a resourceful gas as recent advances in the area of cell signaling
are revealing an unexpected physiological role for CO in the cardiovascular, immune and …

CORM‐A1: a new pharmacologically active carbon monoxide‐releasing molecule

R Motterlini, P Sawle, S Bains, J Hammad… - The FASEB …, 2005 - Wiley Online Library
Carbon monoxide (CO) is emerging as an important and versatile mediator of physiological
processes to the extent that treatment of animals with exogenous CO gas has beneficial …

Carbon monoxide and its controlled release: therapeutic application, detection, and development of carbon monoxide releasing molecules (CORMs) miniperspective

K Ling, F Men, WC Wang, YQ Zhou… - Journal of Medicinal …, 2017 - ACS Publications
Carbon monoxide (CO) is attracting increasing attention because of its role as a
gasotransmitter with cytoprotective and homeostatic properties. Carbon monoxide releasing …

Developing drug molecules for therapy with carbon monoxide

CC Romao, WA Blättler, JD Seixas… - Chemical Society …, 2012 - pubs.rsc.org
The use of Carbon Monoxide (CO) as a therapeutic agent has already been tested in human
clinical trials. Pre-clinically, CO gas administration proved beneficial in animal models of …

Development of triggerable, trackable, and targetable carbon monoxide releasing molecules

LS Lazarus, AD Benninghoff… - Accounts of chemical …, 2020 - ACS Publications
Conspectus Carbon monoxide (CO) is a gaseous signaling molecule produced in humans
via the breakdown of heme in an O2-dependent reaction catalyzed by heme oxygenase …

Controlled therapeutic delivery of CO from carbon monoxide-releasing molecules (CORMs)

HI Choi, A Zeb, MS Kim, I Rana, N Khan… - Journal of Controlled …, 2022 - Elsevier
Carbon monoxide (CO) has been regarded as a “silent killer” for its toxicity toward biological
systems. However, a low concentration of endogenously produced CO has shown a number …

Strategies toward organic carbon monoxide prodrugs

X Ji, B Wang - Accounts of Chemical Research, 2018 - ACS Publications
Conspectus Carbon monoxide is widely acknowledged as an important gasotransmitter in
the mammalian system with importance on par with that of nitric oxide. It has also been firmly …

A click-and-release approach to CO prodrugs

D Wang, E Viennois, K Ji, K Damera… - Chemical …, 2014 - pubs.rsc.org
Carbon monoxide belongs to the family of signaling molecules and has been shown to
possess therapeutic effects. Similar to NO, safe delivery of CO is a key issue in developing …

Therapeutic applications of carbon monoxide-releasing molecules

R Motterlini, BE Mann, R Foresti - Expert opinion on investigational …, 2005 - Taylor & Francis
Carbon monoxide (CO), which is formed in mammalian cells through the oxidation of haem
by the enzyme haem oxygenase, actively participates in the regulation of key intracellular …