Methoxylated flavones: occurrence, importance, biosynthesis

A Berim, DR Gang - Phytochemistry reviews, 2016 - Springer
Lipophilic flavones with several methoxyl residues occur in various clades of land plants,
from liverworts to core eudicots. Their chemodiversity is mediated by the manifold …

[HTML][HTML] The roles of a flavone-6-hydroxylase and 7-O-demethylation in the flavone biosynthetic network of sweet basil

A Berim, DR Gang - Journal of Biological Chemistry, 2013 - ASBMB
Lipophilic flavonoids found in the Lamiaceae exhibit unusual 6-and 8-hydroxylations whose
enzymatic basis is unknown. We show that crude protein extracts from peltate trichomes of …

A Set of Regioselective O-Methyltransferases Gives Rise to the Complex Pattern of Methoxylated Flavones in Sweet Basil

A Berim, DC Hyatt, DR Gang - Plant Physiology, 2012 - academic.oup.com
Polymethoxylated flavonoids occur in a number of plant families, including the Lamiaceae.
To date, the metabolic pathways giving rise to the diversity of these compounds have not …

[HTML][HTML] Flavones: from biosynthesis to health benefits

N Jiang, AI Doseff, E Grotewold - Plants, 2016 - mdpi.com
Flavones correspond to a flavonoid subgroup that is widely distributed in the plants, and
which can be synthesized by different pathways, depending on whether they contain C-or O …

Feedback inhibition of the general phenylpropanoid and flavonol biosynthetic pathways upon a compromised flavonol-3-O-glycosylation

R Yin, B Messner, T Faus-Kessler… - Journal of …, 2012 - academic.oup.com
Flavonols, phenylalanine-derived secondary metabolites, have protective and regulatory
functions in plants. In Arabidopsis thaliana, they are consecutively glycosylated at their 3-OH …

Flavones and flavone synthases

S Martens, A Mithöfer - Phytochemistry, 2005 - Elsevier
Within the secondary metabolite class of flavonoids which consist of more than 9000 known
structures, flavones define one of the largest subgroups. Their natural distribution is …

[HTML][HTML] Molecular characterization and functional expression of flavonol 6-hydroxylase

D Anzellotti, RK Ibrahim - BMC Plant Biology, 2004 - Springer
Background Flavonoids, one of the major groups of secondary metabolites, play important
roles in the physiology, ecology and defence of plants. Their wide range of activities is the …

Molecular basis for chemical evolution of flavones to flavonols and anthocyanins in land plants

DD Li, R Ni, PP Wang, XS Zhang, PY Wang… - Plant …, 2020 - academic.oup.com
During the course of evolution of land plants, different classes of flavonoids, including
flavonols and anthocyanins, sequentially emerged, facilitating adaptation to the harsh …

Characterization of two candidate flavone 8-O-methyltransferases suggests the existence of two potential routes to nevadensin in sweet basil

A Berim, DR Gang - Phytochemistry, 2013 - Elsevier
Regioselective 6-, 7-, 8-, 3′-, and 4′-O-methylations underlie the structural diversity of
lipophilic flavones produced in the trichomes of sweet basil (Ocimum basilicum L.). The …

Characterization of three distinct flavonol O-methyltransferases from Chrysosplenium americanum

V de Luca, RK Ibrahim - Phytochemistry, 1982 - Elsevier
The partially purified O-methyltransferase (OMT) system of Chrysosplenium americanum
was found to catalyse the stepwise O-methylation of quercetin to its mono-, di-and trimethyl …