The use of amorphous solid dispersions is an interesting strategy to increase the
bioavailability of poorly soluble drugs by improving their rate and extent of dissolution. Lack …

Poorly water-soluble drugs pose a significant challenge to developability due to poor oral
absorption leading to poor bioavailability. Several approaches exist that improve the oral …

Solid dispersion has emerged as a method of choice and has been extensively investigated
to ascertain the in vivo improved performance of many drug formulations. It generally …

Amorphous solid dispersions (ASDs) are being employed frequently to improve
bioavailability of poorly soluble molecules by enhancing the rate and extant of dissolution in …

The alarming numbers of poorly soluble discovery compounds have centered the efforts
towards finding strategies to improve the solubility. One of the attractive approaches to …

The transformation to an amorphous form is one of the most promising approaches to
address the low solubility of drug compounds, the latter being an increasing challenge in the …

Introduction: Poor aqueous solubility of active pharmaceutical ingredients (APIs) is one of
the main challenges in the development of new small molecular drugs. Additionally, the …

Amorphous solid dispersions (ASDs) are a promising formulation approach to improve the
solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. ASDs have …

Amorphous solid dispersions are one of the most promising strategies to improve the oral
bioavailability of sparingly water-soluble drugs. Drug particle size reduction improved the …

The amorphous solid state offers an improved apparent solubility and dissolution rate.
However, due to thermodynamic instability and recrystallization tendencies during …