A pH‐sensitive, biobased calcium carbonate aragonite nanocrystal as a novel anticancer delivery system

A Shafiu Kamba, M Ismail… - BioMed research …, 2013 - Wiley Online Library
The synthesised biobased calcium carbonate nanocrystals had demonstrated to be an
effective carrier for delivery of anticancer drug doxorubicin (DOX). The use of these …

In Vitro Delivery and Controlled Release of Doxorubicin for Targeting Osteosarcoma Bone Cancer

SA Kamba, M Ismail, SH Hussein-Al-Ali, TAT Ibrahim… - Molecules, 2013 - mdpi.com
Drug delivery systems are designed to achieve drug therapeutic index and enhance the
efficacy of controlled drug release targeting with specificity and selectivity by successful …

Designing pH-dependent systems based on nanoscale calcium carbonate for the delivery of an antitumor drug

V Popova, Y Poletaeva, I Pyshnaya, D Pyshnyi… - Nanomaterials, 2021 - mdpi.com
Materials based on calcium carbonate (CaCO3) are widely used in biomedical research (eg,
as carriers of bioactive substances). The biocompatibility of CaCO3 and dependence of its …

Formulation of a sustained release docetaxel loaded cockle shell-derived calcium carbonate nanoparticles against breast cancer

NI Hammadi, Y Abba, MNM Hezmee, ISA Razak… - Pharmaceutical …, 2017 - Springer
Purpose Here, we explored the formulation of a calcium carbonate nanoparticle delivery
system aimed at enhancing docetaxel (DTX) release in breast cancer. Methods The …

Calcium carbonate nanoparticles as cancer drug delivery system

S Maleki Dizaj, M Barzegar-Jalali… - Expert opinion on …, 2015 - Taylor & Francis
Introduction: Calcium carbonate (CaCO3) has broad biomedical utilizations owing to its
availability, low cost, safety, biocompatibility, pH-sensitivity and slow biodegradability …

In situ mineralization of anticancer drug into calcium carbonate monodisperse nanospheres and their pH-responsive release property

T Yang, Z Wan, Z Liu, H Li, H Wang, N Lu… - Materials Science and …, 2016 - Elsevier
In this paper, we facilitated the preparation of uniform calcium carbonate nanospheres and
the encapsulation of anticancer drug (Doxorubicin, Dox) in one step by a facile bio-inspired …

In vitro evaluation of a novel pH sensitive drug delivery system based cockle shell-derived aragonite nanoparticles against osteosarcoma

W Fu, MH Mohd Noor, LM Yusof… - Journal of …, 2017 - Taylor & Francis
Background: Osteosarcoma (OS) is a highly malignant primary bone cancer. Severe side
effects and multidrug resistance are obstacles faced with chemotherapy against OS. With the …

pH-responsive delivery of doxorubicin from citrate–apatite nanocrystals with tailored carbonate content

I Rodríguez-Ruiz, JM Delgado-López… - Langmuir, 2013 - ACS Publications
In this work, the efficiency of bioinspired citrate-functionalized nanocrystalline apatites as
nanocarriers for delivery of doxorubicin (DOXO) has been assessed. The nanoparticles …

Preparation and characterization of calcium carbonate microspheres and their potential application as drug carriers

J Song, R Wang, Z Liu, H Zhang - Molecular medicine …, 2018 - spandidos-publications.com
The influence of lecithin from egg yolk (LE) on calcium carbonate (CaCO3) biomineralization
was investigated. In the present study, spherical CaCO3 particles were synthesized via …

An update on calcium carbonate nanoparticles as cancer drug/gene delivery system

S Maleki Dizaj, S Sharifi, E Ahmadian… - Expert opinion on …, 2019 - Taylor & Francis
Introduction In recent years, the applications of calcium carbonate (CaCO3) nanoparticles
(NPs) have gained extensive interest as targeted drug/gene delivery systems to cancerous …