In humans, neuroligin-3 mutations are associated with autism, whereas in mice, the
corresponding mutations produce robust synaptic and behavioral changes. However …

Multiple candidate genes have been identified for autism spectrum disorders. While some of
these genes reach genome‐wide significance, others, such as the R451C point mutation in …

Multiple independent mutations in neuroligin genes were identified in patients with familial
autism, including the R451C substitution in neuroligin-3 (NL3). Previous studies showed that …

Neuroligins (NLs) are a family of neural cell-adhesion molecules that are involved in
excitatory/inhibitory synapse specification. Multiple members of the NL family (including …

Background Aggression is common in patients with autism spectrum disorders (ASD) along
with the core symptoms of impairments in social communication and repetitive behavior …

Loss-of-function mutations in the synaptic adhesion protein Neuroligin-4 are among the
most common genetic abnormalities associated with autism spectrum disorders, but little is …

Neuroligins are evolutionarily conserved postsynaptic cell adhesion molecules that interact
with presynaptic neurexins. Neurons express multiple neuroligin isoforms that are targeted …

Autism spectrum disorders (ASDs) are characterized by impairments in social behaviors that
are sometimes coupled to specialized cognitive abilities. A small percentage of ASD patients …

Neuroligin‐3 is a member of the class of cell adhesion proteins that mediate synapse
development and have been implicated in autism. Mice with the human R451C mutation …

Gastrointestinal (GI) problems constitute an important comorbidity in many patients with
autism. Multiple mutations in the neuroligin family of synaptic adhesion molecules are …