Background Specialized endoderm‐derived epithelial cells, that is, enteroendocrine cells
(EEC s), are widely distributed throughout the gastrointestinal (GI) tract. Enteroendocrine …

Enteroendocrine cells (EEC) form the basis of the largest endocrine system in the body.
They secrete multiple regulatory molecules which control physiological and homeostatic …

Satiety and other core physiological functions are modulated by sensory signals arising from
the surface of the gut. Luminal nutrients and bacteria stimulate epithelial biosensors called …

The enteroendocrine system orchestrates how the body responds to the ingestion of foods,
employing a diversity of hormones to fine-tune a wide range of physiological responses both …

Of all the organ systems in the body, the gastrointestinal tract is the most complicated in
terms of the numbers of structures involved, each with different functions, and the numbers …

Enteroendocrine cells (EECs) sense intestinal content and release hormones to regulate
gastrointestinal activity, systemic metabolism, and food intake. Little is known about the …

The activity of the digestive system is dynamically regulated by external factors, including
body nutritional and activity states, emotions and the contents of the digestive tube. The gut …

The intestinal epithelium must balance efficient absorption of nutrients with partitioning
commensals and pathogens from the bodies' largest immune system. If this crucial barrier …

Inflammation of the gastrointestinal (GI) tract has pronounced effects on GI function. Many of
the functions of the GI tract are subject to neural regulation by the enteric nervous system …

Gut hormones play a key role in the regulation of food intake, energy expenditure, glucose
homeostasis, lipid metabolism, and a wide range of metabolic functions in response to food …