Risk assessment and communication tools for genotype associations with multifactorial phenotypes: the concept of “edge effect” and cultivating an ethical bridge …

V Ozdemir, G Suarez-Kurtz, R Stenne… - OMICS A Journal of …, 2009 - liebertpub.com
Applications of omics technologies in the postgenomics era swiftly expanded from rare
monogenic disorders to multifactorial common complex diseases, pharmacogenomics, and …

Genome–environment interactions and prospective technology assessment: evolution from pharmacogenomics to nutrigenomics and ecogenomics

V Ozdemir, AG Motulsky, E Kolker… - OMICS A Journal of …, 2009 - liebertpub.com
The relationships between food, nutrition science, and health outcomes have been mapped
over the past century. Genomic variation among individuals and populations is a new factor …

Multi-omics study for interpretation of genome-wide association study

M Akiyama - Journal of Human Genetics, 2021 - nature.com
Genome-wide association studies (GWASs) have identified thousands of genetic loci
associated with complex traits, including a wide variety of diseases. Despite the successful …

Methods of integrating data to uncover genotype–phenotype interactions

MD Ritchie, ER Holzinger, R Li… - Nature Reviews …, 2015 - nature.com
Recent technological advances have expanded the breadth of available omic data, from
whole-genome sequencing data, to extensive transcriptomic, methylomic and metabolomic …

[HTML][HTML] The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological …

MD Ritchie, K Van Steen - Annals of translational medicine, 2018 - ncbi.nlm.nih.gov
One of the primary goals in this era of precision medicine is to understand the biology of
human diseases and their treatment, such that each individual patient receives the best …

Explaining additional genetic variation in complex traits

MR Robinson, NR Wray, PM Visscher - Trends in Genetics, 2014 - cell.com
Genome-wide association studies (GWAS) have provided valuable insights into the genetic
basis of complex traits, discovering> 6000 variants associated with> 500 quantitative traits …

From genotypes to genometypes: putting the genome back in genome-wide association studies

JH Moore - European journal of human genetics, 2009 - nature.com
Human genetics has a long his-tory of benefiting from technological advances that have
made it possible to measure genomic variation. Research over the last 5 years has focused …

Evidence-based management of nutrigenomics expectations and ELSIs

V Ozdemir, B Godard - Pharmacogenomics, 2007 - Taylor & Francis
Nutrigenomics is a new application context for genomics technologies that focuses on the
bidirectional study of genetic factors influencing host (individuals 'or populations ') response …

Embracing complex associations in common traits: critical considerations for precision medicine

MA Hall, JH Moore, MD Ritchie - Trends in Genetics, 2016 - cell.com
Genome-wide association studies (GWAS) have identified numerous loci associated with
human phenotypes. This approach, however, does not consider the richly diverse and …

Phenome-wide association studies: embracing complexity for discovery

SA Pendergrass, A Verma, A Okula, MA Hall… - Human …, 2015 - karger.com
The inherent complexity of biological systems can be leveraged for a greater understanding
of the impact of genetic architecture on outcomes, traits, and pharmacological response. The …