Bcl‐2 family members are the arbiters of mitochondrial apoptotic pathway, which is
conserved through evolution. The stoichiometry of pro‐versus antiapoptotic Bcl‐2 family …

Highlights•BH3s initiate apoptosis by activating BAX/BAK or inactivating anti-death BCL-
2s.•BID, BIM, PUMA, and NOXA directly induce stepwise bimodal activation of BAX and …

The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as
either promoters or inhibitors of cell death. The functional interplay and balance between the …

Apoptosis is a morphologically and biochemically distinct form of cell death that plays an
essential role in development, immune response, and tissue homeostasis. Diminished …

Apoptosis is a critical process for the maintenance of tissue homeostasis and prevention of
tumorigenesis. The members of the Bcl-2 family of proteins are the central regulators of the …

Apoptosis is an essential physiological process for the selective elimination of cells, which is
involved in a variety of biological events. The Bcl‐2 family is the best characterized protein …

The localization and control of Bcl-2 proteins on mitochondria is essential for the intrinsic
pathway of apoptosis. Anti-apoptotic Bcl-2 proteins reside on the outer mitochondrial …

Apoptosis is a biological process that removes damaged, excess or infected cells through a
genetically controlled mechanism. This process plays a crucial role in organismal …

The most prominent function of proteins of the Bcl-2 family is regulation of the initiation of
intrinsic (mitochondrial) pathways of apoptosis. However, recent research has revealed that …

Programmed cell death (apoptosis) is crucial for embryogenesis and tissue homeostasis.
Deregulated apoptosis leads to immunodeficiency, autoimmune disorders or cancer. The …