Platelet vegetations or thrombi are common findings in subacute bacterial endocarditis. We
investigated the hypothesis that human platelets selectively bind or adhere strains of …

There is growing evidence that platelets play an important role in the development of
infective endocarditis IE. This review focuses on interactions between bacteria and platelets …

The basis of similarities in the mechanism of human platelet aggregation induced by soluble
collagen and the dental plaque bacterium Streptococcus sanguis was analyzed. Structural …

Platelet aggregation plays an important role in the pathogenesis of infective endocarditis
induced by viridans streptococci or staphylococci. Aggregation induced in vitro involves …

The ability of certain strains of Streptococcus sanguis to aggregate human platelets in vitro
may be related to their virulence in the pathogenesis of infective endocarditis. We have …

The direct aggregation of platelets is thought to be an important event in the pathogenesis of
viridans streptococcal endocarditis, but the mechanisms for platelet activation are unknown …

The binding of viridans group streptococci with human platelets was analyzed by two-color
flow cytometry. Binding was detected within 15 s of mixing bacteria and platelets. At ratios of …

Heat-killed group A Streptococcus pyogenes induced platelet aggregation in platelet-rich
plasma. Aggregation was dependent upon the ratio of platelets to bacteria, with maximal …

Platelets aggregate in response to an adhesin and the platelet aggregation-associated
protein (PAAP) expressed on the cell surfaces of certain strains of Streptococcus sanguis …

Platelet aggregation is believed to be a virulence factor in infective endocarditis. Other
factors may be adhesion to components of thrombotic vegetations, particularly platelets …