Acetaminophen (APAP) overdosing is a major cause of acute liver failure worldwide and an
established model for drug-induced acute liver injury (ALI). While studying gene expression …

Hepatocyte death during acetaminophen (APAP) intoxication elicits a reactive inflammatory
response, with hepatic recruitment of neutrophils and monocytes, which further aggravates …

Background & Aims Acetaminophen (APAP)-induced acute liver injury (AILI) is a leading
cause of acute liver failure (ALF). N-acetylcysteine (NAC) is only effective within 24 h after …

Intense neutrophil infiltration into the liver is a characteristic of acetaminophen-induced
acute liver injury. Neutrophil elastase is released by neutrophils during inflammation. To …

Acetaminophen (APAP) overdose–induced hepatotoxicity is the leading cause of drug-
induced liver injury worldwide. The related injury pathogenesis is mainly focused on the …

Background: Drug-induced liver injury is a rare but serious clinical problem. A number of
drugs can cause severe liver injury and acute liver failure at therapeutic doses in a very …

Acetaminophen (APAP) overdose is currently the most frequent cause of drug‐induced liver
failure in the U nited S tates. Recently, it was shown that lysosomal iron translocates to …

Acetaminophen (APAP) is a commonly used pain and fever reliever but is also the most
frequent cause of drug-induced liver injury. The mechanism pertaining acetaminophen …

Acetaminophen (APAP) is the most commonly used over-the-counter analgesic. However,
hepatotoxicity induced by APAP is a major clinical issue, and the factors that define …

Acetaminophen (APAP) poisoning is one of the leading causes of acute hepatic failure and
liver transplantation is often the only lifesaving alternative. During the course of hepatocyte …