Importance Although classic psychedelic medications have shown promise in the treatment
of alcohol use disorder (AUD), the efficacy of psilocybin remains unknown. Objective To …

Several lines of evidence suggest that classic (5HT2A agonist) hallucinogens have clinically
relevant effects in alcohol and drug addiction. Although recent studies have investigated the …

Background Psychedelic-assisted therapy [eg, with lysergic acid diethylamide (LSD)] has
shown promising results as treatment for substance use disorders (SUDs). Previous …

Hallucinogenic mushrooms have been used in religious and cultural ceremonies for
centuries. Of late, psilocybin, the psychoactive compound in hallucinogenic mushrooms, has …

After a hiatus of some 40 years, clinical research has resumed on the use of classic
hallucinogens to treat addiction. Following completion of a small open-label feasibility study …

For most psychiatric disorders, including alcohol use disorder (AUD), approved
pharmacological treatments are limited in their effectiveness, and new drugs that can easily …

Several pilot studies have provided evidence supporting the potential of classic
psychedelics like psilocybin in the treatment of substance use disorders (SUDs). If larger …

Research on the clinical applications of psychedelic-assisted psychotherapy has
demonstrated promising early results for treatment of alcohol dependence. Detailed …

Importance The US Food and Drug Administration recognizes total abstinence and no heavy
drinking days as outcomes for pivotal pharmacotherapy trials for alcohol use disorder (AUD) …

Psilocybin and other 5-hydroxytryptamine 2A agonist classic psychedelics have been used
for centuries as sacraments within indigenous cultures. In the mid-twentieth century they …