Cellular response of the blood-brain barrier to injury: potential biomarkers and therapeutic targets for brain regeneration

MM Tenreiro, R Ferreira, L Bernardino, MA Brito - Neurobiology of Disease, 2016 - Elsevier
Endothelial cells are the main component of the blood-brain barrier (BBB), a vital structure
for maintaining brain homeostasis that is seriously disrupted in various neurological …

Functional morphology of the blood–brain barrier in health and disease

S Liebner, RM Dijkhuizen, Y Reiss, KH Plate… - Acta …, 2018 - Springer
The adult quiescent blood–brain barrier (BBB), a structure organised by endothelial cells
through interactions with pericytes, astrocytes, neurons and microglia in the neurovascular …

Blood-brain barrier dysfunction as a potential therapeutic target for neurodegenerative disorders

A Uprety, Y Kang, SY Kim - Archives of pharmacal research, 2021 - Springer
The blood-brain barrier (BBB) is composed of specific tight junction proteins and
transporters expressed on the lining of endothelial cells of the vasculature in the brain. The …

Blood–brain barrier endothelial cells in neurodegenerative diseases: signals from the “barrier”

Y Yuan, J Sun, Q Dong, M Cui - Frontiers in Neuroscience, 2023 - frontiersin.org
As blood–brain barrier (BBB) disruption emerges as a common problem in the early stages
of neurodegenerative diseases, the crucial roles of barrier-type brain endothelial cells …

Blood–brain barrier breakdown in stress and neurodegeneration: biochemical mechanisms and new models for translational research

AB Salmina, YK Komleva, NA Malinovskaya… - Biochemistry …, 2021 - Springer
Blood-brain barrier (BBB) is a structural and functional element of the neurovascular unit
(NVU), which includes cells of neuronal, glial, and endothelial nature. The main functions of …

The blood–brain barrier in neurodegenerative disease: a rhetorical perspective

PM Carvey, B Hendey… - Journal of …, 2009 - Wiley Online Library
Recent studies suggest that the function of the blood–brain barrier (BBB) is not static under
normal physiologic conditions and is likely altered in neurodegenerative disease. Prevailing …

Brain injury-induced dysfunction of the blood brain barrier as a risk for dementia

EE Abrahamson, MD Ikonomovic - Experimental Neurology, 2020 - Elsevier
The blood-brain barrier (BBB) is a complex and dynamic physiological interface between
brain parenchyma and cerebral vasculature. It is composed of closely interacting cells and …

Establishment of an In Vitro Model of Human Blood–Brain Barrier to Study the Impact of Ischemic Injury

RRA Kadir, M Alwjwaj, U Bayraktutan - The Blood-Brain Barrier: Methods …, 2022 - Springer
The blood–brain barrier (BBB), mainly composed of brain microvascular endothelial cells,
astrocyte end-feet, and pericytes, serves as a physical and biochemical barrier that …

The blood-brain barrier in health and chronic neurodegenerative disorders

BV Zlokovic - Neuron, 2008 - cell.com
The blood-brain barrier (BBB) is a highly specialized brain endothelial structure of the fully
differentiated neurovascular system. In concert with pericytes, astrocytes, and microglia, the …

In vivo methods for imaging blood–brain barrier function and dysfunction

WJ Harris, MC Asselin, R Hinz, LM Parkes… - European journal of …, 2023 - Springer
The blood–brain barrier (BBB) is the interface between the central nervous system and
systemic circulation. It tightly regulates what enters and is removed from the brain …