Fas ligand (FasL) binds Fas (CD95) to induce apoptosis or activate other signaling
pathways. In addition, FasL transduces bidirectional or 'reverse signals'. The intracellular …

Fas Ligand (FasL, CD178) is a cytokine that may be secreted or expressed as a
transmembrane ligand at the cell surface, and induces apoptosis by binding to the “death …

The Fas antigen (Apo1/CD95) is a transmembrane protein belonging to the nerve growth
factor receptor family. It is expressed on a variety of cells, including activated T lymphocytes …

Background-Fas ligand is a cytotoxic effector molecule of T and NK cells which is
characterized by an intracellular N-terminal polyproline region that serves as a docking site …

Abstract Fas (CD95, APO-1), a member of the TNF superfamily, is a prototypical “death
receptor” which transduces apoptotic signals in a variety of cell types. However, cell death is …

Abstract Fas ligand (FasL) and Fas are mediators of apoptosis, which are implicated in the
peripheral deletion of autoimmune cells, activation-induced T cell death, and cytotoxicity …

Cross‐linking of Fas and Fas ligand (FasL) induces apoptosis in Fas‐bearing cells and
regulates apoptosis. Fas is widely expressed in normal human tissues, but FasL expression …

Fas ligand (FasL, CD95L, APO-1L, CD178, TNFSF6, APT1LG1) is the key death factor of
receptor-triggered programmed cell death in immune cells. FasL/Fas-dependent apoptosis …

The interaction of Fas (CD95), a member of the tumor necrosis factor receptor (TNFR) family,
and its ligand (FasL) triggers programmed cell death (apoptosis) and is involved in the …

As a death factor of T cells and Natural Killer (NK) cells, Fas Ligand (FasL) is stored in
association with secretory lysosomes. Upon stimulation, these cytotoxic granules are …