The gasdermin (GSDM) superfamily has been demonstrated to consist of several important
molecules that modulate multifunctional signal processes, such as cell pyroptosis. In this …

Gasdermin D (GSDMD) is a newly discovered pyroptosis executive protein, which can be
cleaved by inflammatory caspases and is essential for secretion of IL‑1β, making it a critical …

Six Gasdermins (GSDM) family members participate in various biological processes
especially pyroptosis, as well as in the initiation and development of many types of cancer …

Gasdermin B (GSDMB) belongs to the gasdermin (GSDM) family which may adopt different
mechanisms of intramolecular domain interactions to modulate their lipid-binding and pore …

Gasdermin B (GSDMB) is part of the gasdermin (GSDM) family, and they use varying means
of domain interactions in molecules to adjust their pore‐forming and lipid‐binding actions …

Gasdermin E (GSDME) is an executioner of caspase-3 mediated regulated pyroptosis, and
as such plays an important role in several cancers. Recent findings highlighted the potential …

Gasdermin B (GSDMB) belongs to the Gasdermin protein family that comprises four
members (GSDMA-D). Gasdermin B expression has been detected in some tumor types …

Gasdermin E (GSDME) is a member of the gasdermin protein family, which mediates
programmed cell death including apoptosis and pyroptosis. Recently, it was suggested that …

Abstract Background Gasdermins (GSDMs)-mediated pyroptosis is widely involved in
activating anti-tumor immunity and suppressing tumor growth. However, whether gasdermin …

Pyroptosis is closely associated with cancer development; however, the role of pyroptosis in
pancreatic ductal adenocarcinoma (PDAC), a fatal malignant tumour with a poor overall …