The repair of large segmental bone defects due to trauma, inflammation and tumor surgery
remains a major clinical problem. Animal models were developed to test bone repair by …

The aim of this review is to characterise the biological and biophysical background of in vitro
bone tissue engineering. The paper focuses on basic principles in extracorporal …

The present article describes the state of the art in the rapidly developing field of bone tissue
engineering, where many disciplines, such as material science, mechanical engineering …

Bone is a tissue with a strong regenerative potential. New strategies for tissue engineering
of bone should therefore only focus on defects with a certain size that will not heal …

The drive to develop bone grafts for the filling of major gaps in the skeletal structure has led
to a major research thrust towards developing biomaterials for bone engineering …

Bone repair was addressed in a critical‐sized defect model in sheep, combining a ceramic
biomaterial and mesenchymal progenitor cells. The defects in the tibial mid‐diaphysis were …

Almost 20 years after the invention of tissue engineering, autogenous bone grafting has
remained the favored strategy for the treatment of bone defects. As an alternative, a vast …

Scaffold‐based bone tissue engineering aims to repair/regenerate bone defects. Such a
treatment concept involves seeding autologous osteogenic cells throughout a …

Bone defects represent a medical and socioeconomic challenge. Different types of
biomaterials are applied for reconstructive indications and receive rising interest. However …

PURPOSE: Maxillofacial reconstructive procedures often require bone graft harvesting,
which results in donor site morbidity; the use of tissue-engineered bone would eliminate this …