Hypoxia has long been implicated in the pathogenesis of fibrotic diseases. Aberrantly
activated myofibroblasts are the primary pathological driver of fibrotic progression, yet how …

Rationale: Dysregulation of cellular metabolism has been shown to participate in several
pathologic processes. However, the role of metabolic reprogramming is not well appreciated …

Idiopathic pulmonary fibrosis (IPF) is characterized by excessive deposition of extracellular
matrix in the lung with fibroblast-to-myofibroblast transition, leading to chronically …

Pulmonary fibrosis is a progressive and intractable lung disease with fibrotic features that
affects alveoli elasticity, which leading to higher rates of hospitalization and mortality …

Pulmonary fibrosis refers to a heterogeneous group of disorders that scar the lung, most
often irreversibly. To date, there are limited effective treatments for these conditions, despite …

Background Idiopathic pulmonary fibrosis (IPF) is an age-related, progressive and lethal
disease, whose pathogenesis is associated with fibroblasts/myofibroblasts foci that produce …

Idiopathic pulmonary fibrosis (IPF) is a chronic lung disorder that is characterized by
aberrant tissue remodeling and the formation of fibroblastic foci that are composed of …

Background Idiopathic pulmonary fibrosis (IPF) is a fatal respiratory disease characterized
by aberrant fibroblast activation and progressive fibrotic remodelling of the lungs. Though …

Fibrosis is the final pathological outcome and major cause of morbidity and mortality in many
common and chronic inflammatory, immune-mediated, and metabolic diseases. Despite the …

Metabolic reprogramming has been intrinsically linked to macrophage activation. Alveolar
macrophages are known to play an important role in the pathogenesis of pulmonary fibrosis …