Protection of retinal ganglion cells in glaucoma: Current status and future

J Shen, Y Wang, K Yao - Experimental Eye Research, 2021 - Elsevier
Glaucoma is a neuropathic disease that causes optic nerve damage, loss of retinal ganglion
cells (RGCs), and visual field defects. Most glaucoma patients have no early signs or …

Retinal ganglion cells and neuroprotection for glaucoma

LA Levin - Survey of ophthalmology, 2003 - Elsevier
Neuroprotection is a therapeutic strategy directed at keeping retinal ganglion cells (RGCs)
alive and functional. This article discusses three commonly asked questions about …

Neuroprotection in glaucoma: animal models and clinical trials

M Almasieh, LA Levin - Annual review of vision science, 2017 - annualreviews.org
Glaucoma is a progressive neurodegenerative disease that frequently results in irreversible
blindness. Glaucoma causes death of retinal ganglion cells (RGCs) and their axons in the …

Who's lost first? Susceptibility of retinal ganglion cell types in experimental glaucoma

L Della Santina, Y Ou - Experimental eye research, 2017 - Elsevier
The purpose of this article is to summarize our current knowledge about the susceptibility of
specific retinal ganglion cell (RGC) types in experimental glaucoma, and to delineate the …

Molecular and cell-based approaches for neuroprotection in glaucoma

F Lebrun-Julien, A Di Polo - Optometry and Vision Science, 2008 - journals.lww.com
A hallmark of glaucomatous optic nerve damage is retinal ganglion cell (RGC) death. RGCs,
like other central nervous system neurons, have a limited capacity to survive or regenerate …

Neuroprotection in glaucoma: basic aspects and clinical relevance

CY Kuo, CJL Liu - Journal of Personalized Medicine, 2022 - mdpi.com
Glaucoma is a neurodegenerative disease that affects primarily the retinal ganglion cells
(RGCs). Increased intraocular pressure (IOP) is one of the major risk factors for glaucoma …

Cell transplantation approaches to retinal ganglion cell neuroprotection in glaucoma

TV Johnson, KR Martin - Current opinion in pharmacology, 2013 - Elsevier
Glaucoma is a complex neurodegenerative disease that involves interactions among
multiple signaling pathways, ultimately leading to progressive retinal ganglion cell (RGC) …

[PDF][PDF] Retinal ganglion cell death in glaucoma: mechanisms and neuroprotective strategies.

MH Kuehn, JH Fingert, YH Kwon - development, 2005 - myweb.uiowa.edu
Neuroprotection can be defined as any therapeutic paradigm designed to prevent or delay
neuronal cell death and maintain neural function. In glaucoma, progressive death of the …

Innovative IOP‐Independent Neuroprotection and Neuroregeneration Strategies in the Pipeline for Glaucoma

JC Tsai - Journal of Ophthalmology, 2020 - Wiley Online Library
While sustained reduction of intraocular pressure (IOP) has been shown to halt and/or delay
the progressive death of retinal ganglion cells (RGCs) in glaucoma, there exists great …

Glaucoma 2.0: neuroprotection, neuroregeneration, neuroenhancement

EE Chang, JL Goldberg - Ophthalmology, 2012 - Elsevier
Glaucoma is a progressive neurodegenerative disease of retinal ganglion cells (RGCs)
associated with characteristic axon degeneration in the optic nerve. Clinically, our only …