Since the discovery of myostatin (MSTN; also known as GDF-8) as a critical regulator of
skeletal muscle mass in 1997, there has been an extensive effort directed at understanding …

Myostatin (MSTN) is a transforming growth factor-β family member that plays a critical role in
regulating skeletal muscle mass. Genetic studies in multiple species have demonstrated that …

Myostatin, also known as growth differentiation factor 8 (GDF8), is a transforming growth
factor-β (TGF-β) family member that functions to limit skeletal muscle growth. Accordingly …

Many growth factors are intimately bound to the extracellular matrix, with regulated
processing and release leading to cellular stimulation. Myostatin and GDF11 are closely …

Myostatin is a member of the transforming growth factor β superfamily of secreted growth
factors that negatively regulates skeletal muscle size. Mice null for the myostatin gene have …

Genetic deletion of Myostatin, a member of the Transforming Growth Factor-beta family of
signalling molecules, resulted in excessive growth of skeletal muscle. It demonstrated the …

Myostatin is a member of the transforming growth factor (TGF)-β superfamily. It is expressed
by animal and human skeletal muscle cells where it limits muscle growth and promotes …

Mutations in myostatin (GDF8) cause marked increases in muscle mass, suggesting that this
transforming growth factor‐β (TGF‐β) superfamily member negatively regulates muscle …

Muscular dystrophies are characterized by weakness and wasting of skeletal muscle
tissues. Several drugs targeting the myostatin pathway have been used in clinical trials to …

Myostatin is an endogenous, negative regulator of muscle growth determining both muscle
fiber number and size. The myostatin pathway is conserved across diverse species ranging …