[HTML][HTML] Targeting the myostatin signaling pathway to treat muscle loss and metabolic dysfunction
SJ Lee - The Journal of clinical investigation, 2021 - Am Soc Clin Investig
Since the discovery of myostatin (MSTN; also known as GDF-8) as a critical regulator of
skeletal muscle mass in 1997, there has been an extensive effort directed at understanding …
skeletal muscle mass in 1997, there has been an extensive effort directed at understanding …
Extracellular regulation of myostatin: a molecular rheostat for muscle mass
SJ Lee - Immunology, Endocrine & Metabolic Agents in …, 2010 - ingentaconnect.com
Myostatin (MSTN) is a transforming growth factor-β family member that plays a critical role in
regulating skeletal muscle mass. Genetic studies in multiple species have demonstrated that …
regulating skeletal muscle mass. Genetic studies in multiple species have demonstrated that …
[HTML][HTML] Myostatin inhibitors: panacea or predicament for musculoskeletal disorders?
J Suh, YS Lee - Journal of bone metabolism, 2020 - ncbi.nlm.nih.gov
Myostatin, also known as growth differentiation factor 8 (GDF8), is a transforming growth
factor-β (TGF-β) family member that functions to limit skeletal muscle growth. Accordingly …
factor-β (TGF-β) family member that functions to limit skeletal muscle growth. Accordingly …
[HTML][HTML] Blocking extracellular activation of myostatin as a strategy for treating muscle wasting
M Pirruccello-Straub, J Jackson, S Wawersik… - Scientific reports, 2018 - nature.com
Many growth factors are intimately bound to the extracellular matrix, with regulated
processing and release leading to cellular stimulation. Myostatin and GDF11 are closely …
processing and release leading to cellular stimulation. Myostatin and GDF11 are closely …
Metabolic functions of myostatin and GDF11
AC McPherron - Immunology, Endocrine & Metabolic Agents in …, 2010 - ingentaconnect.com
Myostatin is a member of the transforming growth factor β superfamily of secreted growth
factors that negatively regulates skeletal muscle size. Mice null for the myostatin gene have …
factors that negatively regulates skeletal muscle size. Mice null for the myostatin gene have …
The function of Myostatin and strategies of Myostatin blockade—new hope for therapies aimed at promoting growth of skeletal muscle
K Patel, H Amthor - Neuromuscular Disorders, 2005 - Elsevier
Genetic deletion of Myostatin, a member of the Transforming Growth Factor-beta family of
signalling molecules, resulted in excessive growth of skeletal muscle. It demonstrated the …
signalling molecules, resulted in excessive growth of skeletal muscle. It demonstrated the …
Myostatin: Basic biology to clinical application
P Esposito, D Picciotto, Y Battaglia, F Costigliolo… - Advances in clinical …, 2022 - Elsevier
Myostatin is a member of the transforming growth factor (TGF)-β superfamily. It is expressed
by animal and human skeletal muscle cells where it limits muscle growth and promotes …
by animal and human skeletal muscle cells where it limits muscle growth and promotes …
Myostatin propeptide‐mediated amelioration of dystrophic pathophysiology
S Bogdanovich, KJ Perkins, TOB Krag… - The FASEB …, 2005 - Wiley Online Library
Mutations in myostatin (GDF8) cause marked increases in muscle mass, suggesting that this
transforming growth factor‐β (TGF‐β) superfamily member negatively regulates muscle …
transforming growth factor‐β (TGF‐β) superfamily member negatively regulates muscle …
[HTML][HTML] Downregulation of myostatin pathway in neuromuscular diseases may explain challenges of anti-myostatin therapeutic approaches
Muscular dystrophies are characterized by weakness and wasting of skeletal muscle
tissues. Several drugs targeting the myostatin pathway have been used in clinical trials to …
tissues. Several drugs targeting the myostatin pathway have been used in clinical trials to …
Myostatin in the pathophysiology of skeletal muscle
A Bonnieu, G Carnac, B Vernus - Current genomics, 2007 - ingentaconnect.com
Myostatin is an endogenous, negative regulator of muscle growth determining both muscle
fiber number and size. The myostatin pathway is conserved across diverse species ranging …
fiber number and size. The myostatin pathway is conserved across diverse species ranging …