[PDF][PDF] Fast principal-component analysis reveals convergent evolution of ADH1B in Europe and East Asia
Searching for genetic variants with unusual differentiation between subpopulations is an
established approach for identifying signals of natural selection. However, existing methods …
established approach for identifying signals of natural selection. However, existing methods …
ADH1B: From alcoholism, natural selection, and cancer to the human phenome
R Polimanti, J Gelernter - … Journal of Medical Genetics Part B …, 2018 - Wiley Online Library
The ADH1B (Alcohol Dehydrogenase 1B (class I), Beta Polypeptide) gene and its best‐
known functional alleles, Arg48His (rs1229984, ADH1B* 2) and Arg370Cys (rs2066702 …
known functional alleles, Arg48His (rs1229984, ADH1B* 2) and Arg370Cys (rs2066702 …
[PDF][PDF] Geographically separate increases in the frequency of the derived ADH1B* 47His allele in eastern and western Asia
H Li, N Mukherjee, U Soundararajan, Z Tárnok… - The American Journal of …, 2007 - cell.com
The ADH1B Arg47His polymorphism has been convincingly associated with alcoholism in
numerous studies of several populations in Asia and Europe. In a review of literature from …
numerous studies of several populations in Asia and Europe. In a review of literature from …
ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry
A coding variant in alcohol dehydrogenase 1B (ADH1B)(rs1229984) that leads to the
replacement of Arg48 with His48 is common in Asian populations and reduces their risk for …
replacement of Arg48 with His48 is common in Asian populations and reduces their risk for …
[PDF][PDF] A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity
MV Osier, AJ Pakstis, H Soodyall, D Comas… - The American Journal of …, 2002 - cell.com
Variants of different Class I alcohol dehydrogenase (ADH) genes have been shown to be
associated with an effect that is protective against alcoholism. Previous work from our …
associated with an effect that is protective against alcoholism. Previous work from our …
[PDF][PDF] Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism
M Osier, AJ Pakstis, JR Kidd, JF Lee, SJ Yin… - The American Journal of …, 1999 - cell.com
Two of the three class I alcohol dehydrogenase (ADH) genes (ADH2 and ADH3) encode
known functional variants that act on alcohol with different efficiencies. Variants at both these …
known functional variants that act on alcohol with different efficiencies. Variants at both these …
[PDF][PDF] Evidence of positive selection on a class I ADH locus
Y Han, S Gu, H Oota, MV Osier, AJ Pakstis… - The American Journal of …, 2007 - cell.com
The alcohol dehydrogenase (ADH) family of enzymes catalyzes the reversible oxidation of
alcohol to acetaldehyde. Seven ADH genes exist in a segment of∼ 370 kb on 4q21 …
alcohol to acetaldehyde. Seven ADH genes exist in a segment of∼ 370 kb on 4q21 …
Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication
BL Park, JW Kim, HS Cheong, LH Kim, BC Lee… - Human genetics, 2013 - Springer
Alcohol dependence (AD) is a multifactorial and polygenic disorder involving complex gene-
to-gene and gene-to-environment interactions. Several genome-wide association studies …
to-gene and gene-to-environment interactions. Several genome-wide association studies …
[PDF][PDF] Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence
X Luo, HR Kranzler, L Zuo, S Wang, NJ Schork… - The American Journal of …, 2006 - cell.com
The set of alcohol-metabolizing enzymes has considerable genetic and functional
complexity. The relationships between some alcohol dehydrogenase (ADH) and aldehyde …
complexity. The relationships between some alcohol dehydrogenase (ADH) and aldehyde …
Allelic variation at alcohol metabolism genes (ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population
CJ Mulligan, RW Robin, MV Osier, N Sambuughin… - Human genetics, 2003 - Springer
Enzymes encoded by two gene families, alcohol dehydrogenase (ADH) and aldehyde
dehydrogenase (ALDH), mediate alcohol metabolism in humans. Allelic variants have been …
dehydrogenase (ALDH), mediate alcohol metabolism in humans. Allelic variants have been …