Mural cells are essential components of blood vessels and are necessary for normal
development, homeostasis, and organ function. Alterations in mural cell density or the stable …

Background Blood vessels comprise endothelial cells, mural cells (pericytes/vascular
smooth muscle cells) and basement membrane. During angiogenesis, mural cells are …

The requirement for notch signaling during vascular development is well‐documented but
poorly understood. Embryonic and adult endothelial cells (EC) express notch and notch …

The past two decades of angiogenesis research have identified a wealth of pro-and
antiangiogenic signals originating from the tissue environment, which control blood vessel …

Endothelial cells and mural cells (smooth muscle cells, pericytes, or fibroblasts) are known
to communicate with one another. Their interactions not only serve to support fully functional …

The Notch signaling pathway plays an essential role in a wide variety of biological
processes including cell fate determination of vascular endothelial cells and the regulation …

Interactions between endothelial cells (ECs) and perivascular mural cells (MCs) via
signaling molecules or physical contacts are implicated both in vascular remodeling and …

Mural cells (pericytes and vascular smooth muscle cells) provide trophic and structural
support to blood vessels. Vascular smooth muscle cells alternate between a …

Angiogenesis, or the formation of new blood vessels from pre-existing ones, is essential to
establish the vascular circuit during embryonic development. During angiogenic sprouting …

The formation of blood vessels within the vascular system entails a variety of cellular
processes, including proliferation, migration and differentiation. In many cases, these …