Synthesis and comprehensive in vivo activity profiling of olean-12-en-28-ol, 3β-pentacosanoate in experimental autoimmune encephalomyelitis: a natural …
Multiple sclerosis (MS) treatment has received much attention, yet there is still no certain
cure. We herein investigate the therapeutic effect of olean-12-en-28-ol, 3β-pentacosanoate …
cure. We herein investigate the therapeutic effect of olean-12-en-28-ol, 3β-pentacosanoate …
[HTML][HTML] Oleanolic acid acetate alleviates symptoms of experimental autoimmune encephalomyelitis in mice by regulating toll-like receptor 2 signaling
M Kim, S Lee, H Lim, J Lee, JY Park… - Frontiers in …, 2020 - frontiersin.org
Toll-like receptor 2 (TLR2) is expressed by several immune cells in the central nervous
system and plays an important role in neuroinflammation. TLR2 upregulation has been …
system and plays an important role in neuroinflammation. TLR2 upregulation has been …
[HTML][HTML] Oleanolic acid ameliorates intestinal alterations associated with EAE
B Gutierrez, I Gallardo, L Ruiz, Y Alvarez… - Journal of …, 2020 - Springer
Background Multiple sclerosis (MS) is a chronic demyelinating autoimmune disease
affecting the CNS. Recent studies have indicated that intestinal alterations play key …
affecting the CNS. Recent studies have indicated that intestinal alterations play key …
Tocopherol derivative TFA-12 promotes myelin repair in experimental models of multiple sclerosis
B Blanchard, T Heurtaux, C Garcia… - Journal of …, 2013 - Soc Neuroscience
Multiple sclerosis (MS) is an inflammatory disease of the CNS that is associated with
demyelination and axonal loss, resulting in severe neurological handicap. Current MS …
demyelination and axonal loss, resulting in severe neurological handicap. Current MS …
Beneficial actions of oleanolic acid in an experimental model of multiple sclerosis: a potential therapeutic role
R Martín, J Carvalho-Tavares, M Hernández… - Biochemical …, 2010 - Elsevier
Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease for which there exist
no therapies without undesired side effects. Thus, the establishment of less toxic treatments …
no therapies without undesired side effects. Thus, the establishment of less toxic treatments …
[HTML][HTML] A co-ultramicronized palmitoylethanolamide/luteolin composite mitigates clinical score and disease-relevant molecular markers in a mouse model of …
G Contarini, D Franceschini, L Facci… - Journal of …, 2019 - Springer
Background Persistent and/or recurrent inflammatory processes are the main factor leading
to multiple sclerosis (MS) lesions. The composite ultramicronized palmitoylethanolamide, an …
to multiple sclerosis (MS) lesions. The composite ultramicronized palmitoylethanolamide, an …
Natural triterpenes modulate immune‐inflammatory markers of experimental autoimmune encephalomyelitis: Therapeutic implications for multiple sclerosis
R Martín, M Hernández, C Cordova… - British Journal of …, 2012 - Wiley Online Library
BACKGROUND AND PURPOSE Multiple sclerosis (MS) and its animal model, experimental
autoimmune encephalomyelitis (EAE), are inflammatory demyelinating diseases that …
autoimmune encephalomyelitis (EAE), are inflammatory demyelinating diseases that …
[HTML][HTML] 4-Ethylguaiacol modulates neuroinflammation and Th1/Th17 differentiation to ameliorate disease severity in experimental autoimmune encephalomyelitis
Background Multiple sclerosis (MS) is a progressive autoimmune disease characterized by
the accumulation of pathogenic inflammatory immune cells in the central nervous system …
the accumulation of pathogenic inflammatory immune cells in the central nervous system …
[HTML][HTML] Oleacein attenuates the pathogenesis of experimental autoimmune encephalomyelitis through both antioxidant and anti-inflammatory effects
B Gutiérrez-Miranda, I Gallardo, E Melliou, I Cabero… - Antioxidants, 2020 - mdpi.com
Oxidative stress and proinflammatory cytokines are factors affecting multiple sclerosis (MS)
disease progression. Oleacein (OLE), an olive secoiridoid, possesses powerful antioxidant …
disease progression. Oleacein (OLE), an olive secoiridoid, possesses powerful antioxidant …
[HTML][HTML] Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis
Inflammatory cytokines and endogenous anti-oxidants are variables affecting disease
progression in multiple sclerosis (MS). Here we demonstrate the dual capacity of …
progression in multiple sclerosis (MS). Here we demonstrate the dual capacity of …