Deep Learning Techniques to Characterize the RPS28P7 Pseudogene and the Metazoa-SRP Gene as Drug Potential Targets in Pancreatic Cancer Patients

I Salgado, E Prado Montes de Oca, I Chairez… - Biomedicines, 2024 - mdpi.com
The molecular explanation about why some pancreatic cancer (PaCa) patients die early and
others die later is poorly understood. This study aimed to discover potential novel markers …

A Novel Perspective on Genes Driving Metastatic Pancreatic Cancer Revealed by Single-cell RNA Sequencing

S Sayad, M Hiatt, H Mustafa - medRxiv, 2024 - medrxiv.org
Background: Pancreatic ductal adenocarcinoma (PDAC) is formidable in its advanced,
metastatic stage. Aggressive spread of malignant cells from the pancreas to distant organs …

[HTML][HTML] Construction of a pyroptosis-related genes signature to improve the prognostic prediction and therapeutic drugs selection in patients with pancreatic cancer

C Li, M Wang, J Wei, W Zhang, H Liu… - International Journal of …, 2022 - ncbi.nlm.nih.gov
Background Effective prognostic assessment and appropriate drug selection are important
for the clinical management of pancreatic cancer (PaC). Here, we aimed to establish a …

Pyroptosis-related genes regulate proliferation and invasion of pancreatic cancer and serve as the prognostic signature for modeling patient survival

W Song, Z Liu, K Wang, K Tan, A Zhao, X Li, Y Yuan… - Discover Oncology, 2022 - Springer
Objective Pancreatic ductal adenocarcinoma (PDAC) has high mortality and poor prognosis.
Pyroptosis can influence the prognosis of patients by regulating the proliferation, invasion …

System analysis based on the pyroptosis-related genes identifies GSDMC as a novel therapy target for pancreatic adenocarcinoma

C Yan, Y Niu, F Li, W Zhao, L Ma - Journal of translational medicine, 2022 - Springer
Background Pancreatic adenocarcinoma (PAAD) is one of the most common malignant
tumors of the digestive tract. Pyroptosis is a newly discovered programmed cell death that …

Five gene signatures were identified in the prediction of overall survival in resectable pancreatic cancer

C Wu, Z Wu, B Tian - BMC surgery, 2020 - Springer
Background Although genes have been previously detected in pancreatic cancer (PC),
aberrant genes that play roles in resectable pancreatic cancer should be further assessed …

[PDF][PDF] Identification by genetic algorithm optimized back propagation artificial neural network and validation of a four-gene signature for diagnosis and prognosis of …

Z Li, Z Ma, Q Zhou, S Wang, Q Yan, H Zhuang, Z Zhou… - Heliyon, 2022 - cell.com
Background Although some improvements in the management of pancreatic cancer (PC)
have been made, no major breakthroughs in terms of biomarker discovery or effective …

[HTML][HTML] Exploring the potential of pyroptosis-related genes in predicting prognosis and immunological characteristics of pancreatic cancer from the perspective of …

J Zhang, X You, D Kang, G Zhou - Frontiers in Oncology, 2022 - frontiersin.org
Objective: To probe into the role of pyroptosis-related genes in pancreatic carcinoma.
Methods: Herein, we conducted a comprehensive bioinformatics analysis to evaluate tumor …

Identification of candidate diagnostic and prognostic biomarkers for pancreatic carcinoma

Y Cheng, K Wang, L Geng, J Sun, W Xu, D Liu… - …, 2019 - thelancet.com
Background Pancreatic carcinoma (PC) is one of the most aggressive cancers affecting
human health. It is essential to identify candidate biomarkers for the diagnosis and …

Dissection of pyroptosis-related prognostic signature and CASP6-mediated regulation in pancreatic adenocarcinoma: New sights to clinical decision-making

J Zhu, Y Shi, S Lan, J Wang, F Jiang, C Tang, Y Cai… - Apoptosis, 2023 - Springer
Recent studies have indicated that pyroptosis may participate in the regulation of
tumorigenesis and immune microenvironment. However, the role of pyroptosis-related …