Misfolding and intracellular aggregation of α-synuclein are thought to be crucial factors in
the pathogenesis of Lewy body diseases (LBDs), such as Parkinson disease. However, the …

Parkinson׳ s disease (PD) is the second most common neurodegenerative disease, and the
most prevalent degenerative movement disorder. It is estimated that the prevalence of such …

Abstract α-Synuclein is an abundantly expressed neuronal protein that is at the center of
focus in understanding a group of neurodegenerative disorders called α-synucleinopathies …

Abstract α-Synuclein is a soluble protein that is present in abundance in the brain, though its
normal function in the healthy brain is poorly defined. Intraneuronal inclusions of α …

Over 20 years ago, the synaptic protein α-synuclein was identified as the primary component
of the Lewy bodies (LBs) that are a sine qua non of Parkinson's disease (PD). Since that …

Starting two decades ago with the discoveries of genetic links between alpha-synuclein and
Parkinson's disease risk and the identification of aggregated alpha-synuclein as the main …

α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …

Misfolding and abnormal aggregation of the neuronal protein α-synuclein has been
implicated in the pathogenesis of Parkinson's disease and related neurological disorders …

These recent findings open up new avenues of investigation into the molecular
pathogenesis of Parkinson's disease. Future work will need to identify the most toxic …

Adverse intra-and extracellular effects of toxic α-synuclein are believed to be central to the
pathogenesis in Parkinson's disease and other disorders with Lewy body pathology in the …