Individuals suffering from substance-use disorders develop strong associations between the
drug's rewarding effects and environmental cues, creating powerful, enduring triggers for …

Epigenetic mechanisms regulate processes of neuroplasticity critical to cocaine-induced
behaviors. This includes the Class I histone deacetylase (HDAC) HDAC3, known to act as a …

Cocaine-induced neuroplasticity mediated by histone acetylating and deacetylating
enzymes may contribute to addiction-like behaviors. For example, overexpression of histone …

Addiction to cocaine is commonly preceded by experiences with legal or decriminalized
drugs, such as alcohol, nicotine, and marijuana. The biological mechanisms by which these …

Chromatin remodeling by histone deacetylases (HDACs) is a key mechanism regulating
behavioral adaptations to cocaine use. We report here that cocaine and cyclic adenosine …

Powerful associations that link drugs of abuse with cues in the drug-paired environment
often serve as prepotent relapse triggers. Drug-associated contexts and cues activate …

Background While dopamine signaling in the nucleus accumbens (NAc) plays a well-
established role in motivating cocaine use in early nonaddicted stages, recent evidence …

Background Cocaine use is often associated with diminished cognitive function, persisting
even after abstinence from the drug. Likely targets for these changes are the core and shell …

Nonspecific histone deacetylase (HDAC) inhibition has been shown to facilitate the
extinction of drug-seeking behavior in a manner resistant to reinstatement. A key open …

The regulation of gene expression in the brain reward regions is known to contribute to the
pathogenesis and persistence of drug addiction. Increasing evidence suggests that the …