Background: Acute myeloid leukaemia (AML) is a disease of the haematopoietic stem cells.
Beta-catenin, a key element of the Wnt signalling, which is particularly active in various …

Background: Growing evidences from both preclinical and clinical investigations reveal the
critical role of Wnt signalling for the development of many cancers and for their response to …

Background Acute myeloid leukemia (AML) is a hematopoietic stem cell disorder
characterized by uncontrolled proliferation and impaired differentiation of normal …

Introduction β-Catenin is a multifunctional protein that acts as a central effector molecule in
the Wnt signaling pathway. Aberrant activation of the Wnt/β-catenin signaling pathway …

Objective To investigate the expression of beta-catenin in patients with leukemia and
explore its significance in leukemias. Methods RT-PCR was used to detect the expression of …

This study was aimed to quantitatively detect the levels of beta-catenin and cyclin D1 mRNA
in various subgroups of acute myeloid leukemia (AML) and to analyze their potential …

Canonical Wnt/β-catenin signaling is frequently dysregulated in myeloid leukemias and is
implicated in leukemogenesis. Nuclear-localized β-catenin is indicative of active Wnt …

Inhibitor of beta-catenin and TCF (ICAT) is a key protein in the Wnt-β-catenin signaling
pathway. However, its role in acute myeloid leukemia (AML) remains unknown. In this study …

Aberrant activation of β-catenin is a common event in AML and is an independent predictor
of poor prognosis. Although increased β-catenin signaling in AML has been associated with …

Activation of the Wnt/β-catenin pathway has recently been shown to be crucial to the
establishment of leukemic stem cells in chronic myeloid leukemia. We sought to determine …