Association between C-reactive protein (CRP) with depression symptom severity and specific depressive symptoms in major depression

O Köhler-Forsberg, HN Buttenschøn, KE Tansey… - Brain, behavior, and …, 2017 - Elsevier
Introduction Population-based studies have associated inflammation, particularly higher C-
reactive protein (CRP), with depressive severity, but clinical trials in major depressive …

Elevated C-reactive protein in patients with depression, independent of genetic, health, and psychosocial factors: results from the UK Biobank

MC Pitharouli, SP Hagenaars… - American Journal of …, 2021 - Am Psychiatric Assoc
Objective: The authors investigated the pathways (genetic, environmental, lifestyle, medical)
leading to inflammation in major depressive disorder using C-reactive protein (CRP) …

Replication and reproducibility issues in the relationship between C-reactive protein and depression: a systematic review and focused meta-analysis

SR Horn, MM Long, BW Nelson, NB Allen… - Brain, behavior, and …, 2018 - Elsevier
One of the most common inflammatory markers examined in depression is C-reactive
protein (CRP). However, the magnitude of the association between CRP and depression …

Elevated C-reactive protein levels, psychological distress, and depression in 73 131 individuals

MK Wium-Andersen, DD Ørsted, SF Nielsen… - JAMA …, 2013 - jamanetwork.com
Context The pathogenesis of depression is not fully understood, but studies suggest that low-
grade systemic inflammation contributes to the development of depression. Objective To test …

Association of high-sensitivity C-reactive protein with de novo major depression

JA Pasco, GC Nicholson, LJ Williams… - The British Journal of …, 2010 - cambridge.org
BackgroundAlthough there is cross-sectional evidence that changes in the immune system
contribute to the pathophysiology of depression, longitudinal data capable of elucidating …

C-reactive protein as a biomarker for major depressive disorder?

L Orsolini, S Pompili, S Tempia Valenta, V Salvi… - International journal of …, 2022 - mdpi.com
The etiopathogenesis of depression is not entirely understood. Several studies have
investigated the role of inflammation in major depressive disorder. The present work aims to …

Treatment-resistant depression and peripheral C-reactive protein

SR Chamberlain, J Cavanagh, P De Boer… - The British Journal of …, 2019 - cambridge.org
BackgroundC-reactive protein (CRP) is a candidate biomarker for major depressive disorder
(MDD), but it is unclear how peripheral CRP levels relate to the heterogeneous clinical …

Association between systemic inflammation and individual symptoms of depression: a pooled analysis of 15 population-based cohort studies

P Frank, M Jokela, GD Batty, D Cadar… - American Journal of …, 2021 - Am Psychiatric Assoc
Objective: Evidence from anti-inflammatory drug trials for the treatment of depression has
been inconsistent. This may be ascribed to the differing symptom-specific effects of …

Association of inflammation with specific symptoms of depression in a general population of older people: The English Longitudinal Study of Ageing

J White, M Kivimäki, M Jokela, GD Batty - Brain, Behavior, and Immunity, 2017 - Elsevier
Elevated levels of inflammatory markers, such as C-reactive protein, are well documented in
people with depression. Few studies have examined whether the association between …

Role of inflammation in depression and anxiety: Tests for disorder specificity, linearity and potential causality of association in the UK Biobank

Z Ye, N Kappelmann, S Moser, GD Smith… - …, 2021 - thelancet.com
Background Concentrations of C-reactive protein (CRP), interleukin 6 (IL-6) and other
inflammatory markers are elevated in people with depression and anxiety compared to …