Background The presence of allergic sensitization has a major influence on the
development and course of common childhood conditions such as asthma and rhinitis. The …

Background Differential DNA methylation associated with allergy might provide novel
insights into the shared or unique etiology of asthma, rhinitis, and eczema. Objective We …

Background DNA methylation (DNAm) is considered a plausible pathway through which
genetic and environmental factors may influence the development of allergies. However …

Background Season of birth influences allergy risk; however, the biological mechanisms
underlying this observation are unclear. The environment affects DNA methylation, with …

Aim: Epigenetic mechanisms are critical for normal immune development and epigenetic
alterations might therefore be possible contributors to immune diseases. To investigate if …

Epigenetic mechanisms integrate both genetic variability and environmental exposures.
However, comprehensive epigenome-wide analysis has not been performed across major …

DNA methylation changes may predispose becoming IgE-sensitized to allergens. We
analyzed whether DNA methylation in peripheral blood mononuclear cells (PBMC) is …

Background Underlying biological mechanisms involved in sex differences in asthma status
changes from pre‐to post‐adolescence are unclear. DNA methylation (DNAm) has been …

Aim: We aim to study DNA methylation (DNAm) variations associated with childhood
asthma. Methods: Nasal DNAm was compared between sibling pairs discordant for asthma …

Childhood allergic diseases, including asthma, rhinitis and eczema, are prevalent conditions
that share strong genetic and environmental components. Diagnosis relies on clinical history …