Abstract People with Li–Fraumeni syndrome (LFS) harbor a germline pathogenic variant in
the TP53 tumor suppressor gene, face a near 100% lifetime risk of cancer, and routinely …

Importance Establishment of an optimal cancer surveillance program is important to reduce
cancer-related morbidity and mortality in individuals with Li-Fraumeni syndrome, a rare …

Li-Fraumeni syndrome (LFS) is an autosomal dominantly inherited condition caused by
germline mutations of the TP53 tumor suppressor gene encoding p53, a transcription factor …

Importance Guidelines for clinical management in Li-Fraumeni syndrome, a multiple-organ
cancer predisposition condition, are limited. Whole-body magnetic resonance imaging …

Context Individuals with Li-Fraumeni syndrome (LFS) have an inherited cancer
predisposition to a diverse array of malignancies beginning early in life; survivors of one …

Abstract Background Li-Fraumeni syndrome (LFS) is an autosomal dominant disease that is
associated with germline TP53 mutations and it predisposes affected individuals to a high …

Li–Fraumeni syndrome (LFS) is a hereditary tumor that exhibits autosomal dominant
inheritance. LFS develops in individuals with a pathogenic germline variant of the cancer …

Abstract Background Li-Fraumeni syndrome (LFS) has traditionally been identified by single-
gene testing (SGT) of TP53 triggered by clinical criteria, but the widespread use of multigene …

Li-Fraumeni syndrome (LFS) is a rare genetic disorder that confers a high risk of developing
certain malignancies at a young age. It is caused by germline mutations in the TP53 gene …

OBJECTIVE. Li-Fraumeni syndrome (LFS) is a rare autosomal-dominant inherited syndrome
containing a germline mutation in the TP53 gene, which predisposes to oncogenesis …