Hydrogel cell encapsulation devices are a common approach to reduce the need for chronic
systemic immunosuppression in allogeneic cell product transplantation …

Cellular macroencapsulation devices, known as tissue engineered grafts (TEGs), enable the
transplantation of allogeneic cells without the need for life-long systemic …

A major barrier to the creation of engineered organs is the limited diffusion of oxygen
through biological tissues. Advances in biofabrication bring us increasingly closer to …

A varying oxygen environment is known to affect cellular function in disease as well as
activity of various therapeutics. For transient structures, whether they are unconstrained …

Insufficient oxygenation is a serious issue arising within cell-based implants, as the hypoxic
period between implantation and vascularization of the graft is largely unavoidable. In situ …

Targeted MRI contrast agents have proven useful in research and clinical studies for
highlighting specific metabolites and biomarkers [Davies GL, et al.(2013) Chem Commun …

Cell microencapsulation within biocompatible polymers is an established technology for
immobilizing living cells that secrete therapeutic products. These can be transplanted into a …

Oxygen is the single most important molecule for sustaining life and, therefore, an important
variable in tissue engineering and regenerative medicine. It has been shown that the …

Different strategies have been employed to provide adequate nutrients for engineered living
tissues. These have mainly revolved around providing oxygen to alleviate the effects of …

Abstract Type 1 diabetes (T1D) is an autoimmune disease that leads to the loss of insulin-
producing beta cells. Bioartificial pancreas (BAP) or beta cell replacement strategies have …