Nanotechnology-Enhanced Cosmetic Application of Kojic Acid Dipalmitate, a Kojic Acid Derivate with Improved Properties

A Ayuhastuti, ISK Syah, S Megantara, AY Chaerunisaa - Cosmetics, 2024 - mdpi.com
Kojic acid (KA) has emerged as a prominent tyrosinase inhibitor with considerable potential
in cosmetic applications; however, its susceptibility to instability during storage poses a …

Review on the use of kojic acid—A skin-lightening ingredient

V Phasha, J Senabe, P Ndzotoyi, B Okole, G Fouche… - Cosmetics, 2022 - mdpi.com
This article reviews the use of Kojic Acid (KA) as a skin-lightening ingredient in the
cosmetics industry. In 1907, Saito discovered KA, a natural product; it has since become one …

Kojic acid-derived tyrosinase inhibitors: synthesis and bioactivity

SM Hashemi, S Emami - Pharmaceutical and Biomedical …, 2015 - pbr.mazums.ac.ir
Tyrosinase is a key enzyme for melanin biosynthesis, catalyzing the oxidation of L-tyrosine
to L-dopaquinone. The tyrosinase inhibition is an effective approach to control …

An improved nanoemulsion formulation containing kojic monooleate: optimization, characterization and in vitro studies

MA Roselan, SE Ashari, NH Faujan, SM Mohd Faudzi… - Molecules, 2020 - mdpi.com
Tyrosinase inhibitors have become increasingly important targets for hyperpigmentation
disease treatment. Kojic monooleate (KMO), synthesized from the esterification of kojic acid …

[HTML][HTML] Kojic acid applications in cosmetic and pharmaceutical preparations

M Saeedi, M Eslamifar, K Khezri - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Skin color disorders can be caused by various factors, such as excessive exposure to
sunlight, aging and hormonal imbalance during pregnancy, or taking some medications …

Development of a kojic monooleate-enriched oil-in-water nanoemulsion as a potential carrier for hyperpigmentation treatment

SNA Syed Azhar, SE Ashari, N Salim - International journal of …, 2018 - Taylor & Francis
Introduction Kojic monooleate (KMO) is an ester derived from a fungal metabolite of kojic
acid with monounsaturated fatty acid, oleic acid, which contains tyrosinase inhibitor to treat …

Nanoemulsion containing kojic dipalmitate and rosehip oil: a promising formulation to treat melasma

JC Zilles, LP Duarte, TC Ruaro, AR Zimmer… - Pharmaceutics, 2023 - mdpi.com
Melasma is a hard-to-treat hyperpigmentation disorder. Combined incorporation of kojic
dipalmitate (KDP), the esterified form of kojic acid, and rosehip oil, an oil with antioxidant …

Biological activities and safety data of kojic acid and its derivatives: A review

JC Zilles, FL Dos Santos… - Experimental …, 2022 - Wiley Online Library
Kojic acid presents a variety of applications for human use, especially as a depigmenting
agent. Its derivatives are also proposed in order to prevent chemical degradation, prevent …

The effect of emulgel preparation on the stability of Kojic acid in the topical anti‐hyperpigmentation products

Y Khadivi, S Shakeri, S Arjmandmazidi… - Journal of Cosmetic …, 2024 - Wiley Online Library
Background The emulgel, a novel drug delivery system, merges emulsion and gel, offering
advantages like enhanced stability, precise control over drug release kinetics, and …

A promising and effective platform for delivering hydrophilic depigmenting agents in the treatment of cutaneous hyperpigmentation: Kojic acid nanostructured lipid …

K Khezri, M Saeedi, K Morteza-Semnani… - Artificial Cells …, 2021 - Taylor & Francis
This study was aimed at preparing and characterising kojic acid nanostructured lipid carriers
(KA-NLCs) for delivery to skin. KA-NLCs were prepared using high-speed homogenization …